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The bronchodilating effect of two doses of peroral enprofylline was compared with placebo in 24 asthmatic patients. Enprofylline produced significantly greater bronchodilatation than placebo. A dose of 2 mg/kg b.wt. and 4 mg/kg b.wt. caused a mean maximal increase in FEV1 of 26% and 35%, respectively. The degree and the incidence of headache and nausea were estimated by means of a scoring system. Dose-related effects on both parameters were observed. Other side effects were negligible. In seven patients the mean plasma half-life of enprofylline was found to be 113 min. It is suggested that enprofylline should be studied further in patients suffering from obstructive lung disease.
L C Laursen, and
N Johannesson, and
A Dirksen, and
R Djurup, and
E P Munch, and
E Taudorf, and
B Weeke
July 1983,
European journal of respiratory diseases,
L C Laursen, and
N Johannesson, and
A Dirksen, and
R Djurup, and
E P Munch, and
E Taudorf, and
B Weeke
August 1987,
Annals of allergy,
L C Laursen, and
N Johannesson, and
A Dirksen, and
R Djurup, and
E P Munch, and
E Taudorf, and
B Weeke
December 1987,
Danish medical bulletin,
L C Laursen, and
N Johannesson, and
A Dirksen, and
R Djurup, and
E P Munch, and
E Taudorf, and
B Weeke
October 1981,
Acta pharmacologica et toxicologica,
L C Laursen, and
N Johannesson, and
A Dirksen, and
R Djurup, and
E P Munch, and
E Taudorf, and
B Weeke
April 1987,
American journal of obstetrics and gynecology,
L C Laursen, and
N Johannesson, and
A Dirksen, and
R Djurup, and
E P Munch, and
E Taudorf, and
B Weeke
July 1996,
The Journal of pharmacy and pharmacology,
L C Laursen, and
N Johannesson, and
A Dirksen, and
R Djurup, and
E P Munch, and
E Taudorf, and
B Weeke
January 1972,
Ftiziologia,
L C Laursen, and
N Johannesson, and
A Dirksen, and
R Djurup, and
E P Munch, and
E Taudorf, and
B Weeke
August 1965,
Therapeutische Umschau. Revue therapeutique,
L C Laursen, and
N Johannesson, and
A Dirksen, and
R Djurup, and
E P Munch, and
E Taudorf, and
B Weeke
March 1986,
Acta pharmacologica et toxicologica,
L C Laursen, and
N Johannesson, and
A Dirksen, and
R Djurup, and
E P Munch, and
E Taudorf, and
B Weeke
January 1982,
European journal of clinical pharmacology,
