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Stereotaxic microinjections of insulin (100 microU) into the ventromedial hypothalamic nucleus (VMN) resulted in rapid decrease, whereas injection of control saline into the same region caused a slight increase of hepatic venous plasma glucose concentration in rats. The hypoglycemic effect of insulin injected into the VMN was eliminated by pretreatment of the animals with atropine but not with propranolol or with phentolamine. Subdiaphragmatic vagotomy also prevented the decrease of hepatic venous plasma glucose concentration seen after microinjection of insulin into the VMN. These results support the hypothesis that the VMN is an insulin-sensitive glucoregulator center or that it is part of one and that the glucoregulatory impulse that originates in the VMN reaches the effector organ, the liver, through the cholinergic fibers of the vagus nerves.
A J Szabo, and
A Iguchi, and
P D Burleson, and
O Szabo
October 1986,
Endocrinology,
A J Szabo, and
A Iguchi, and
P D Burleson, and
O Szabo
January 1997,
Neuroreport,
A J Szabo, and
A Iguchi, and
P D Burleson, and
O Szabo
October 2020,
Neuroscience letters,
A J Szabo, and
A Iguchi, and
P D Burleson, and
O Szabo
May 1999,
Brain research,
A J Szabo, and
A Iguchi, and
P D Burleson, and
O Szabo
July 1988,
The Journal of clinical investigation,
A J Szabo, and
A Iguchi, and
P D Burleson, and
O Szabo
June 2020,
The Journal of clinical investigation,
A J Szabo, and
A Iguchi, and
P D Burleson, and
O Szabo
June 1994,
Brain research,
A J Szabo, and
A Iguchi, and
P D Burleson, and
O Szabo
January 1998,
Nutritional neuroscience,
A J Szabo, and
A Iguchi, and
P D Burleson, and
O Szabo
January 2023,
ASN neuro,
A J Szabo, and
A Iguchi, and
P D Burleson, and
O Szabo
March 2005,
Brain research bulletin,
