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The presence as well as the cellular and subcellular distribution of S-100 protein were investigated in lymphoid organs of the adult rat by quantitative microcomplement fixation assay and by the immunocytochemical PAP method at the ultrastructural level. The protein appeared to be confined to the "follicular dendritic" cells both in the lymph node and the spleen, which are known to be exclusively associated with B lymphocytes in secondary follicles. The present data show an additional location for S-100 outside the nervous system. The protein may also be a useful tool to provide information on the origin and function of "follicular dendritic" cells, which are still poorly understood.
D Cocchia, and
G Tiberio, and
R Santarelli, and
F Michetti
November 1981,
Brain research,
D Cocchia, and
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January 1982,
Cell and tissue research,
D Cocchia, and
G Tiberio, and
R Santarelli, and
F Michetti
January 1997,
Molecular and chemical neuropathology,
D Cocchia, and
G Tiberio, and
R Santarelli, and
F Michetti
January 1988,
The International journal of biological markers,
D Cocchia, and
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September 1993,
Experimental cell research,
D Cocchia, and
G Tiberio, and
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July 1998,
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica,
D Cocchia, and
G Tiberio, and
R Santarelli, and
F Michetti
January 1985,
Cell and tissue research,
D Cocchia, and
G Tiberio, and
R Santarelli, and
F Michetti
January 1981,
Cell and tissue research,
D Cocchia, and
G Tiberio, and
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F Michetti
January 1986,
Virchows Archiv. A, Pathological anatomy and histopathology,
D Cocchia, and
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January 1981,
Cell and tissue research,
