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Gentamicin serum levels were determined in 113 children of different ages (premature infants, full-term neonates, infants, older children) using a rapid microbiological method. It turned out to be favourable to take blood samples at two different times (30 and 120 min after administration of drug). In this way we found out the maximum concentration in serum and moreover by determining the serum half-life the velocity of elimination of the drug. In the group of premature infants mean serum half-life was 3.88 h and significantly longer than serum halflife in the group of older children (1.76 h) or full-term neonates (2.64 h). Children suffering from urological diseases showed a slower excretion of gentamicin, even when creatinine and urea concentrations in serum were not elevated. The rapid microbiological method used turned out to be reliable, simple and time-saving.
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Zhonghua xin xue guan bing za zhi,
