-transparent.png){kind=logo}
The replication origin of the E. coli K-12 chromosome has been isolated as autonomously replicating molecules(oriC plasmid), and the DNA region essential for replicating function(oriC) has been localized to a sequence of 232-245 base-pairs(bp) by deletion analysis. In this report, the functional role of oriC was analysed by using an in vitro replication system and various OriC+ and OriC- plasmids previously constructed. The results obtained were summarized as follows: (1) The oriC sequence contained information enough to direct bidirectional replication. (2) The actual DNA replication began at a region near, but outside, oriC and progressed bidirectionally. (3) Initiation of DNA synthesis at the specific region required the dnaA-complementing fraction from cells harboring a dnaA-carrying plasmid.
S Tabata, and
A Oka, and
K Sugimoto, and
M Takanami, and
S Yasuda, and
Y Hirota
August 1984,
Cell,
S Tabata, and
A Oka, and
K Sugimoto, and
M Takanami, and
S Yasuda, and
Y Hirota
January 1991,
Research in microbiology,
S Tabata, and
A Oka, and
K Sugimoto, and
M Takanami, and
S Yasuda, and
Y Hirota
January 1979,
Cold Spring Harbor symposia on quantitative biology,
S Tabata, and
A Oka, and
K Sugimoto, and
M Takanami, and
S Yasuda, and
Y Hirota
January 2017,
Advances in experimental medicine and biology,
S Tabata, and
A Oka, and
K Sugimoto, and
M Takanami, and
S Yasuda, and
Y Hirota
December 1977,
Molecular & general genetics : MGG,
S Tabata, and
A Oka, and
K Sugimoto, and
M Takanami, and
S Yasuda, and
Y Hirota
August 1980,
Journal of bacteriology,
S Tabata, and
A Oka, and
K Sugimoto, and
M Takanami, and
S Yasuda, and
Y Hirota
October 1997,
Molecular microbiology,
S Tabata, and
A Oka, and
K Sugimoto, and
M Takanami, and
S Yasuda, and
Y Hirota
January 1984,
Advances in experimental medicine and biology,
S Tabata, and
A Oka, and
K Sugimoto, and
M Takanami, and
S Yasuda, and
Y Hirota
April 1973,
Nature: New biology,
S Tabata, and
A Oka, and
K Sugimoto, and
M Takanami, and
S Yasuda, and
Y Hirota
October 1972,
Proceedings of the National Academy of Sciences of the United States of America,
