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Uptake of isologous DNA (labeled with 3H-thymidine) by L-cells was investigated by means of electron microscopic autoradiography. It was found that exogenous 3H-DNA occurred not only in the cytoplasm, but, already from the 1st hr of incubation, permeated as far as in the host cell nuclei. During continuous cultivation, radioactivity established in the nuclei and cytoplasm increases with maximum value after 12 hr incubation. Beginning at the 3rd hr of incubation, in cytoplasma, grain clusters over loci of higher radioactivity were found. After 24 hr incubation, similar grain clusters in L-cell nuclei were observed. In the cytoplasma of the cells, the grains were often determined over or in the vicinity of lysosomes; in the nuclei they were localized predominantly over heterochromatine. The manner of 3H-DNA and 3H-TdR labeling was also compared.
S Viklická, and
J Keprtová, and
L Tkadlecek, and
M Cibulka, and
E Minárová
January 1974,
Izvestiia Akademii nauk SSSR. Seriia biologicheskaia,
S Viklická, and
J Keprtová, and
L Tkadlecek, and
M Cibulka, and
E Minárová
December 1977,
The Journal of comparative neurology,
S Viklická, and
J Keprtová, and
L Tkadlecek, and
M Cibulka, and
E Minárová
January 1970,
Experimental cell research,
S Viklická, and
J Keprtová, and
L Tkadlecek, and
M Cibulka, and
E Minárová
January 1971,
Acta medicinae Okayama,
S Viklická, and
J Keprtová, and
L Tkadlecek, and
M Cibulka, and
E Minárová
January 1991,
Cellular and molecular biology,
S Viklická, and
J Keprtová, and
L Tkadlecek, and
M Cibulka, and
E Minárová
January 1986,
Cell and tissue research,
S Viklická, and
J Keprtová, and
L Tkadlecek, and
M Cibulka, and
E Minárová
January 1979,
Cell and tissue research,
S Viklická, and
J Keprtová, and
L Tkadlecek, and
M Cibulka, and
E Minárová
March 1976,
Journal of cell science,
S Viklická, and
J Keprtová, and
L Tkadlecek, and
M Cibulka, and
E Minárová
April 1974,
The American journal of anatomy,
S Viklická, and
J Keprtová, and
L Tkadlecek, and
M Cibulka, and
E Minárová
July 1994,
Arzneimittel-Forschung,
