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Cardiac allografting was carried out in 33 patients during the past 2 years. Twenty-one (64%) of the patients are alive and others lived for different periods after transplantation. The number of HLA-AB and HLA-DR antigens matched or mismatched was not significantly different between the surviving and deceased patients. However, 100% (4 of the 4) of the patients with a positive serum crossmatch with donor T lymphocytes are deceased as compared to the 25% (7 of the 28) mortality rate for crossmatch-negative patients. All four of the deceased patients with a positive crossmatch had demonstrable deposition of immunoglobulins in the capillaries of the donor heart at autopsy, whereas no immunoglobulin or fibrinogen deposition was seen in the hearts of crossmatch-negative patients. Three of the four patients with positive crossmatches had sera cytotoxic to lymphocytes of more than 25% of the persons, of a 42 member panel, whereas in the remaining one the serum was cytotoxic to less than 5% of the panel members. In crossmatch-negative patients, the sera were cytotoxic to less than 20% of the panel members with one exception. The relevance of cytotoxic antibodies to lymphocytes of panel members, crossmatch, and tissue deposition of immunoglobulins is discussed.
G Singh, and
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R Bernstein, and
B S Rabin, and
R Hardesty, and
M Nalesnik, and
H T Bahnson
January 2006,
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G Singh, and
M Thompson, and
B Griffith, and
R Bernstein, and
B S Rabin, and
R Hardesty, and
M Nalesnik, and
H T Bahnson
November 2023,
Pediatric transplantation,
G Singh, and
M Thompson, and
B Griffith, and
R Bernstein, and
B S Rabin, and
R Hardesty, and
M Nalesnik, and
H T Bahnson
August 1996,
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G Singh, and
M Thompson, and
B Griffith, and
R Bernstein, and
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M Nalesnik, and
H T Bahnson
January 1971,
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G Singh, and
M Thompson, and
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R Bernstein, and
B S Rabin, and
R Hardesty, and
M Nalesnik, and
H T Bahnson
September 2012,
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia,
G Singh, and
M Thompson, and
B Griffith, and
R Bernstein, and
B S Rabin, and
R Hardesty, and
M Nalesnik, and
H T Bahnson
January 1993,
Clinical transplants,
G Singh, and
M Thompson, and
B Griffith, and
R Bernstein, and
B S Rabin, and
R Hardesty, and
M Nalesnik, and
H T Bahnson
June 2003,
Clinical transplantation,
G Singh, and
M Thompson, and
B Griffith, and
R Bernstein, and
B S Rabin, and
R Hardesty, and
M Nalesnik, and
H T Bahnson
January 2007,
Immunologic research,
G Singh, and
M Thompson, and
B Griffith, and
R Bernstein, and
B S Rabin, and
R Hardesty, and
M Nalesnik, and
H T Bahnson
August 1990,
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G Singh, and
M Thompson, and
B Griffith, and
R Bernstein, and
B S Rabin, and
R Hardesty, and
M Nalesnik, and
H T Bahnson
July 1979,
Clinical nuclear medicine,
