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We have investigated the influence of subinhibitory concentrations of chloramphenicol, erythromycin, penicillin G and gentamicin on the phagocytosis and the virulence in the mouse of strains of group A beta-haemolytic streptococci. In most cases, an increase of the phagocytosis and a decrease of the virulence were shown. The maximum effect have been observed in concentration ranging from 1/2 to 1/8 of the respective MIC. In one strain, the virulence was enhanced in the presence of 1/2 and 1/4 MIC of chloramphenicol and 1/2 of erythromycin, in spite of the fact that the phagocytosis was increased in these concentrations of drugs. The importance of hyaluronic acid as virulence factor has been investigated and discussed.
J Michel, and
M Ferne, and
M Rotenberg
January 1987,
Reviews of infectious diseases,
J Michel, and
M Ferne, and
M Rotenberg
November 1959,
Journal of bacteriology,
J Michel, and
M Ferne, and
M Rotenberg
January 1986,
Revista do Instituto de Medicina Tropical de Sao Paulo,
J Michel, and
M Ferne, and
M Rotenberg
October 1975,
Bulletin of the New York Academy of Medicine,
J Michel, and
M Ferne, and
M Rotenberg
July 1974,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
J Michel, and
M Ferne, and
M Rotenberg
March 1977,
The Journal of antimicrobial chemotherapy,
J Michel, and
M Ferne, and
M Rotenberg
August 2022,
Microbiology spectrum,
J Michel, and
M Ferne, and
M Rotenberg
February 2004,
Chest,
J Michel, and
M Ferne, and
M Rotenberg
June 1985,
European journal of clinical microbiology,
J Michel, and
M Ferne, and
M Rotenberg
July 2013,
The Journal of antimicrobial chemotherapy,
