-transparent.png){kind=logo}
Prostacyclin (PG I2) generated by vascular endothelium is a strong antiaggregating substance. As platelet aggregation and release of humoral factor(s) have been reported to be crucial in the pathogenesis of acute lung injury following pulmonary microembolization, prostacyclin could have a protective effect against microembolic lung vascular injury. Following unilateral microembolization, the filtration coefficient in the nonembolized lung increased significantly to 0.14 +/- 0.02 from the base line value of 0.07 +/- 0.01 ml/min/mmHg/100g. Prostacyclin as measured as 6-keto PG F1 alpha in arterial blood increased significantly to 4.15 +/- 1.76 at 30 min from the base line value of 1.90 +/- 0.45 ng/ml and increased further to 5.67 +/- 1.49 ng/ml at 60 min following microembolization. Exogenously administered PG I2 methylester (20 ng/kg/min) prevented completely the increase in the filtration coefficient without any effects on hemodynamics, although the effects of PG I2 methylester did not depend on its action on platelet aggregation. Based on these results, we conclude that prostacyclin could play an important role in preserving cell integrity of the lung and prevention of increased lung vascular permeability following pulmonary microembolization.
T Hirose, and
E Aoki, and
M Domae, and
M Ishibashi, and
T Ikeda, and
K Tanaka
August 1981,
Journal of applied physiology: respiratory, environmental and exercise physiology,
T Hirose, and
E Aoki, and
M Domae, and
M Ishibashi, and
T Ikeda, and
K Tanaka
May 1986,
The Journal of trauma,
T Hirose, and
E Aoki, and
M Domae, and
M Ishibashi, and
T Ikeda, and
K Tanaka
January 1984,
Masui. The Japanese journal of anesthesiology,
T Hirose, and
E Aoki, and
M Domae, and
M Ishibashi, and
T Ikeda, and
K Tanaka
August 1981,
Nihon Kyobu Shikkan Gakkai zasshi,
T Hirose, and
E Aoki, and
M Domae, and
M Ishibashi, and
T Ikeda, and
K Tanaka
March 1984,
The American journal of physiology,
T Hirose, and
E Aoki, and
M Domae, and
M Ishibashi, and
T Ikeda, and
K Tanaka
October 1982,
The American journal of pathology,
T Hirose, and
E Aoki, and
M Domae, and
M Ishibashi, and
T Ikeda, and
K Tanaka
January 1995,
Respiration; international review of thoracic diseases,
T Hirose, and
E Aoki, and
M Domae, and
M Ishibashi, and
T Ikeda, and
K Tanaka
November 1986,
The American review of respiratory disease,
T Hirose, and
E Aoki, and
M Domae, and
M Ishibashi, and
T Ikeda, and
K Tanaka
May 1972,
Indian journal of experimental biology,
T Hirose, and
E Aoki, and
M Domae, and
M Ishibashi, and
T Ikeda, and
K Tanaka
January 1989,
Journal of applied physiology (Bethesda, Md. : 1985),
