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A preparative regimen, consisting of total lymphoid irradiation and cyclophosphamide, was utilized in 40 patients with severe aplastic anemia undergoing allogeneic marrow transplantation. This regimen was successful in decreasing rejection in these previously transfused patients, as only one patient rejected the marrow graft. Twenty-nine of the 40 transplanted patients are surviving from 1.5 to 59 mo, with a median follow-up of 24 mo. The actuarial survival rate for these heavily transfused patients with aplastic anemia is 72% at 2 yr. This preparative regimen is extremely effective in decreasing rejection following transplantation for severe aplastic anemia. Future efforts in this area must be aimed at the elimination of graft-versus-host disease and control of fatal infections.
N K Ramsay, and
T H Kim, and
P McGlave, and
A Goldman, and
M E Nesbit, and
W Krivit, and
W G Woods, and
J H Kersey
January 1989,
Zhonghua Minguo xiao er ke yi xue hui za zhi [Journal]. Zhonghua Minguo xiao er ke yi xue hui,
N K Ramsay, and
T H Kim, and
P McGlave, and
A Goldman, and
M E Nesbit, and
W Krivit, and
W G Woods, and
J H Kersey
October 1996,
International journal of hematology,
N K Ramsay, and
T H Kim, and
P McGlave, and
A Goldman, and
M E Nesbit, and
W Krivit, and
W G Woods, and
J H Kersey
January 2008,
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation,
N K Ramsay, and
T H Kim, and
P McGlave, and
A Goldman, and
M E Nesbit, and
W Krivit, and
W G Woods, and
J H Kersey
September 1988,
Bone marrow transplantation,
N K Ramsay, and
T H Kim, and
P McGlave, and
A Goldman, and
M E Nesbit, and
W Krivit, and
W G Woods, and
J H Kersey
July 2007,
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation,
N K Ramsay, and
T H Kim, and
P McGlave, and
A Goldman, and
M E Nesbit, and
W Krivit, and
W G Woods, and
J H Kersey
June 1987,
La Radiologia medica,
N K Ramsay, and
T H Kim, and
P McGlave, and
A Goldman, and
M E Nesbit, and
W Krivit, and
W G Woods, and
J H Kersey
August 1999,
Bone marrow transplantation,
N K Ramsay, and
T H Kim, and
P McGlave, and
A Goldman, and
M E Nesbit, and
W Krivit, and
W G Woods, and
J H Kersey
January 1991,
Radiation medicine,
N K Ramsay, and
T H Kim, and
P McGlave, and
A Goldman, and
M E Nesbit, and
W Krivit, and
W G Woods, and
J H Kersey
January 1984,
Progress in clinical and biological research,
N K Ramsay, and
T H Kim, and
P McGlave, and
A Goldman, and
M E Nesbit, and
W Krivit, and
W G Woods, and
J H Kersey
December 1996,
Hematological oncology,
