-transparent.png){kind=logo}
Twenty-seven subjects with asthma and normal baseline lung function were challenged with aerosols of methacholine (M) and by isocapnic hyperventilation with cold air (HV). Stimulus-effect relationships were determined for each provocational technique on separate days and were expressed as the dose required to produce a 20% fall in forced expired volume in 1 sec (FEV1) obtained by linear interpolation from log stimulus vs. response curves (PD20). Each stimulus was applied with a sufficient intensity to produce a 20% or greater fall in FEV1 in each subject. The PD20 for M correlated significantly with the PD20 for HV (p less than 0.001) when the latter was expressed in liters per minute. The correlation between cumulative M PD20 and HV PD20 expressed as a percent of maximal voluntary ventilation was significant but less strong. We conclude that the airway response to HV reflects nonspecific bronchial hyperresponsiveness and that the dose of HV is best determined as the absolute level of ventilation.
J W Weiss, and
T H Rossing, and
E R McFadden, and
R H Ingram
January 1988,
Pulmonary pharmacology,
J W Weiss, and
T H Rossing, and
E R McFadden, and
R H Ingram
December 1984,
Thorax,
J W Weiss, and
T H Rossing, and
E R McFadden, and
R H Ingram
March 1982,
The American review of respiratory disease,
J W Weiss, and
T H Rossing, and
E R McFadden, and
R H Ingram
January 2005,
Pulmonary pharmacology & therapeutics,
J W Weiss, and
T H Rossing, and
E R McFadden, and
R H Ingram
July 2002,
Chest,
J W Weiss, and
T H Rossing, and
E R McFadden, and
R H Ingram
June 1985,
Thorax,
J W Weiss, and
T H Rossing, and
E R McFadden, and
R H Ingram
August 1984,
Thorax,
J W Weiss, and
T H Rossing, and
E R McFadden, and
R H Ingram
January 1991,
Pediatric pulmonology,
J W Weiss, and
T H Rossing, and
E R McFadden, and
R H Ingram
January 1982,
European journal of respiratory diseases. Supplement,
J W Weiss, and
T H Rossing, and
E R McFadden, and
R H Ingram
November 1981,
The Journal of allergy and clinical immunology,
