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In mice, the juxtaglomerular cells were examined using qualitative and quantitative electron microscopy after an administration of captopril. After treatment with captopril for 2, 7 and 14 days, the specific granules were decreased in number, the Golgi apparatus was well developed, and the rough endoplasmic reticulum was dilated in profile. In the dilated rough endoplasmic reticulum, the intracisternal granules were occasionally seen after a 2-day treatment, were increased in size and number after a 7-day treatment and were hardly seen after a 14-day treatment. In a few cells associated with intracisternal granules on the 7th day, the Golgi apparatus was not well developed and some lysosomal bodies containing granules similar to the intracisternal granules were seen. In these cells, an excess of the intracisternal granules may be controlled by lysosomes. These findings suggest that the juxtaglomerular cells stimulate renin synthesis after long-term treatment with captopril, but a further increase in renin synthesis cannot be expected after the 7th day.
M Kaneta, and
K Abe, and
T Ito
April 1956,
Klinische Wochenschrift,
M Kaneta, and
K Abe, and
T Ito
January 1979,
Neoplasma,
M Kaneta, and
K Abe, and
T Ito
August 1994,
The American journal of surgical pathology,
M Kaneta, and
K Abe, and
T Ito
July 1996,
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience,
M Kaneta, and
K Abe, and
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June 1979,
The Tohoku journal of experimental medicine,
M Kaneta, and
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T Ito
January 1982,
Annals of clinical and laboratory science,
M Kaneta, and
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T Ito
September 1972,
Clinical orthopaedics and related research,
M Kaneta, and
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August 1984,
Endocrinologia japonica,
M Kaneta, and
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T Ito
January 1964,
Verhandlungen der Anatomischen Gesellschaft,
M Kaneta, and
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T Ito
January 1974,
Pflugers Archiv : European journal of physiology,
