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Twenty-eight patients with advanced life-threatening metastatic malignant melanoma were treated with high dose (140-260 mgm-2) intravenous melphalan and autologous bone marrow. Cyclophosphamide "priming" 300 mgm-2 i.v. was given to 19 patients one week previously and this resulted in clinical but not histological evidence of amelioration of gastrointestinal toxicity. In 11 patients (43%) there was evidence of tumour response to treatment and in 2 patients complete remissions were observed. However in most patients, responses were short-lived and no patient lived longer than 17 months from start of treatment or 24 months from first recorded evidence of distant metastatic disease.
M A Cornbleet, and
T J McElwain, and
P J Kumar, and
J Filshie, and
P Selby, and
R L Carter, and
D W Hedley, and
M L Clark, and
J L Millar
January 1986,
Cancer chemotherapy and pharmacology,
M A Cornbleet, and
T J McElwain, and
P J Kumar, and
J Filshie, and
P Selby, and
R L Carter, and
D W Hedley, and
M L Clark, and
J L Millar
July 1989,
Bone marrow transplantation,
M A Cornbleet, and
T J McElwain, and
P J Kumar, and
J Filshie, and
P Selby, and
R L Carter, and
D W Hedley, and
M L Clark, and
J L Millar
May 1985,
Cancer treatment reports,
M A Cornbleet, and
T J McElwain, and
P J Kumar, and
J Filshie, and
P Selby, and
R L Carter, and
D W Hedley, and
M L Clark, and
J L Millar
January 1979,
Experimental hematology,
M A Cornbleet, and
T J McElwain, and
P J Kumar, and
J Filshie, and
P Selby, and
R L Carter, and
D W Hedley, and
M L Clark, and
J L Millar
December 1989,
Onkologie,
M A Cornbleet, and
T J McElwain, and
P J Kumar, and
J Filshie, and
P Selby, and
R L Carter, and
D W Hedley, and
M L Clark, and
J L Millar
December 1982,
American journal of clinical oncology,
M A Cornbleet, and
T J McElwain, and
P J Kumar, and
J Filshie, and
P Selby, and
R L Carter, and
D W Hedley, and
M L Clark, and
J L Millar
May 1986,
Blood,
M A Cornbleet, and
T J McElwain, and
P J Kumar, and
J Filshie, and
P Selby, and
R L Carter, and
D W Hedley, and
M L Clark, and
J L Millar
January 1982,
British journal of cancer,
M A Cornbleet, and
T J McElwain, and
P J Kumar, and
J Filshie, and
P Selby, and
R L Carter, and
D W Hedley, and
M L Clark, and
J L Millar
April 1985,
Transplantation proceedings,
M A Cornbleet, and
T J McElwain, and
P J Kumar, and
J Filshie, and
P Selby, and
R L Carter, and
D W Hedley, and
M L Clark, and
J L Millar
December 1987,
British journal of haematology,
