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Histologic studies of liver tissue from 27 patients given up to 395 mCi (cumulative) of intravenous colloidal 198Au showed no definite radiation injury and no correlation between hepatic abnormalities and dose. Demonstration of aggregates of colloidal gold in the Kupffer cells was inconsistent, suggesting slow removal or dispersion. Although the liver ordinarily receives the highest radiation dose, the critical organ is the marrow. Results support the recent introduction of 198Au to supplement teletherapy for certain neoplasms diffusely infiltrating the liver. Apparently the beta distribution minimizes endothelial injury in large vessels, which has been shown to be the cause of radiation hepatitis.
B M Nelson, and
G A Andrews, and
E E Watson
May 1957,
Clinical science,
B M Nelson, and
G A Andrews, and
E E Watson
August 1978,
Meditsinskaia radiologiia,
B M Nelson, and
G A Andrews, and
E E Watson
January 1964,
Urologia internationalis,
B M Nelson, and
G A Andrews, and
E E Watson
January 1969,
Polski przeglad radiologii i medycyny nuklearnej,
B M Nelson, and
G A Andrews, and
E E Watson
January 1956,
Giornale di medicina militare,
B M Nelson, and
G A Andrews, and
E E Watson
November 1973,
International journal of nuclear medicine and biology,
B M Nelson, and
G A Andrews, and
E E Watson
February 1980,
Meditsinskaia radiologiia,
B M Nelson, and
G A Andrews, and
E E Watson
June 1976,
RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin,
B M Nelson, and
G A Andrews, and
E E Watson
October 1977,
Acta radiologica: therapy, physics, biology,
B M Nelson, and
G A Andrews, and
E E Watson
July 1954,
Comptes rendus hebdomadaires des seances de l'Academie des sciences,
