BIOMAT Database Logo BIOMAT Database Logo

[In vitro synergy between sulfamethoxazole and trimethoprim on strains of Staphylococcus aureus sensitive and resistant to methicillin]. 1983

R Bismuth, and V Jarlier, and J Grosset

The synergy between sulfamethoxazole (SMZ) and trimethoprim (TMP) is studied on 91 methicillin sensitive S. aureus strains (methi.S) and 95 methicillin resistant S. aureus strains (methi.R). In methi.S strains, the MIC 90% of SMZ, TMP and SMZ + TMP (19 SMZ/1 TMP) is respectively 64, 0.5 and 2 mg/l. 98% of methi.S strains have a FIC index less than or equal to 0.6 and only one strain has a FIC index greater than or equal to 0.6. In methi.R strains, the MIC 90% of SMZ, TMP and SMZ + TMP is respectively 256, 0.5 and 4 mg/l. 77% of methi.R strains have a FIC index less than or equal to 0.6. The relationship between FIC index and disc diffusion method is studied: bridging inhibition zone between SMZ 200 mcg disc, and TMP 2.5 micrograms disc and difference of the inhibition diameter between SMZ + TMP disc and TMP 1.25 micrograms disc. There is a good correlation only in methi.S strains in the first method and in methi.S and methi.R strains in the second method.

UI MeSH Term Description Entries
D008712 Methicillin One of the PENICILLINS which is resistant to PENICILLINASE but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection. Penicillin, Dimethoxyphenyl,Methicillin Hydrate, Monosodium Salt,Methicillin Monohydrate, Monosodium Salt,Methicillin Sodium,Meticillin,Metin,Staphcillin,Dimethoxyphenyl Penicillin
D008826 Microbial Sensitivity Tests Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses). Bacterial Sensitivity Tests,Drug Sensitivity Assay, Microbial,Minimum Inhibitory Concentration,Antibacterial Susceptibility Breakpoint Determination,Antibiogram,Antimicrobial Susceptibility Breakpoint Determination,Bacterial Sensitivity Test,Breakpoint Determination, Antibacterial Susceptibility,Breakpoint Determination, Antimicrobial Susceptibility,Fungal Drug Sensitivity Tests,Fungus Drug Sensitivity Tests,Sensitivity Test, Bacterial,Sensitivity Tests, Bacterial,Test, Bacterial Sensitivity,Tests, Bacterial Sensitivity,Viral Drug Sensitivity Tests,Virus Drug Sensitivity Tests,Antibiograms,Concentration, Minimum Inhibitory,Concentrations, Minimum Inhibitory,Inhibitory Concentration, Minimum,Inhibitory Concentrations, Minimum,Microbial Sensitivity Test,Minimum Inhibitory Concentrations,Sensitivity Test, Microbial,Sensitivity Tests, Microbial,Test, Microbial Sensitivity,Tests, Microbial Sensitivity
D010403 Penicillin Resistance Nonsusceptibility of an organism to the action of penicillins. Penicillin Resistances,Resistance, Penicillin,Resistances, Penicillin
D004357 Drug Synergism The action of a drug in promoting or enhancing the effectiveness of another drug. Drug Potentiation,Drug Augmentation,Augmentation, Drug,Augmentations, Drug,Drug Augmentations,Drug Potentiations,Drug Synergisms,Potentiation, Drug,Potentiations, Drug,Synergism, Drug,Synergisms, Drug
D013211 Staphylococcus aureus Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.
D013420 Sulfamethoxazole A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208) Sulfamethylisoxazole,Gantanol,Sulfisomezole,Sulphamethoxazole
D014295 Trimethoprim A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported. Proloprim,Trimpex

Related Publications

R Bismuth, and V Jarlier, and J Grosset
Synergy between gemifloxacin and trimethoprim/sulfamethoxazole against community-associated methicillin-resistant Staphylococcus aureus.
December 2008, The Journal of antimicrobial chemotherapy,
R Bismuth, and V Jarlier, and J Grosset
In vitro susceptibility of methicillin-resistant Staphylococcus aureus to sulfamethoxazole and trimethoprim.
November 1973, The Journal of infectious diseases,
R Bismuth, and V Jarlier, and J Grosset
[In vitro sensitivity of methicillin-resistant Staphylococcus aureus to fusidic acid and trimethoprim-sulfamethoxazole].
April 2002, Mikrobiyoloji bulteni,
R Bismuth, and V Jarlier, and J Grosset
Trimethoprim-sulfamethoxazole for methicillin-resistant Staphylococcus aureus: a forgotten alternative?
April 2009, Journal of chemotherapy (Florence, Italy),
R Bismuth, and V Jarlier, and J Grosset
Untargeted lipidomic differences between clinical strains of methicillin-sensitive and methicillin-resistant Staphylococcus aureus.
July 2022, Infectious diseases (London, England),
R Bismuth, and V Jarlier, and J Grosset
Interaction between methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA).
October 2003, The Journal of hospital infection,
R Bismuth, and V Jarlier, and J Grosset
[Postsurgery meningitis by Staphylococcus aureus: comparison between methicillin-sensitive and resistant strains].
January 2005, Medicina clinica,
R Bismuth, and V Jarlier, and J Grosset
Oral rifampin and trimethoprim/sulfamethoxazole therapy in asymptomatic carriers of methicillin-resistant Staphylococcus aureus infections.
May 1984, The Western journal of medicine,
R Bismuth, and V Jarlier, and J Grosset
In vitro and in vivo efficacy of the combination trimethoprim-sulfamethoxazole against clinical isolates of methicillin-resistant Staphylococcus aureus.
June 1986, Antimicrobial agents and chemotherapy,
R Bismuth, and V Jarlier, and J Grosset
Methicillin-resistant staphylococcus aureus strains.
February 1973, Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie,
Copied contents to your clipboard!