Biomaterial Database

Nonketotic hyperglycemia associated with loxapine and amoxapine: case report. 1983

G Tollefson, and T Lesar

A case of nonketotic hyperglycemic coma associated with the recent introduction of loxapine is presented. Drug discontinuation led to a return of normal fasting blood glucose. Later challenge with amoxapine was also associated with acute hyperglycemia. Their common metabolite, 7-OH amoxapine, is implicated.

UI	MeSH Term	Description	Entries
D007328	Insulin	A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).	Iletin,Insulin A Chain,Insulin B Chain,Insulin, Regular,Novolin,Sodium Insulin,Soluble Insulin,Chain, Insulin B,Insulin, Sodium,Insulin, Soluble,Regular Insulin
D008152	Loxapine	An antipsychotic agent used in SCHIZOPHRENIA.	Loxapinsuccinate,Oxilapine,2-Chloro-11-(4-methyl-1-piperazinyl)-dibenz(b,f)(1,4)oxazepine,CL-71,563,Cloxazepine,Loxapine Hydrochloride,Loxapine Monohydrochloride,Loxapine Succinate,Loxipine Maleate,Loxipine Succinate,Loxitane,CL 71,563,CL71,563,Hydrochloride, Loxapine,Maleate, Loxipine,Succinate, Loxapine
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D003926	Diabetic Coma	A state of unconsciousness as a complication of diabetes mellitus. It occurs in cases of extreme HYPERGLYCEMIA or extreme HYPOGLYCEMIA as a complication of INSULIN therapy.	Coma, Diabetic,Comas, Diabetic,Diabetic Comas
D003989	Dibenzoxazepines
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006944	Hyperglycemic Hyperosmolar Nonketotic Coma	A serious complication of TYPE 2 DIABETES MELLITUS. It is characterized by extreme HYPERGLYCEMIA; DEHYDRATION; serum hyperosmolarity; and depressed consciousness leading to COMA in the absence of KETOSIS and ACIDOSIS.	Coma, Hyperglycemic Hyperosmolar Nonketotic,Hyperosmolar Hyperglycemic Nonketotic Coma,Hyperosmolar Hyperglycemic State,Hyperosmolar Hyperglycemic Syndrome,Hyperosmolar Nonketotic Coma,Nonketotic Hyperglycemic Coma,Nonketotic Hyperosmolar Coma,Coma, Hyperosmolar Nonketotic,Coma, Nonketotic Hyperglycemic,Coma, Nonketotic Hyperosmolar,Comas, Hyperosmolar Nonketotic,Comas, Nonketotic Hyperosmolar,Hyperglycemic Coma, Nonketotic,Hyperglycemic State, Hyperosmolar,Hyperglycemic States, Hyperosmolar,Hyperglycemic Syndrome, Hyperosmolar,Hyperglycemic Syndromes, Hyperosmolar,Hyperosmolar Coma, Nonketotic,Hyperosmolar Comas, Nonketotic,Hyperosmolar Hyperglycemic States,Hyperosmolar Hyperglycemic Syndromes,Hyperosmolar Nonketotic Comas,Nonketotic Coma, Hyperosmolar,Nonketotic Comas, Hyperosmolar,Nonketotic Hyperosmolar Comas,Syndrome, Hyperosmolar Hyperglycemic,Syndromes, Hyperosmolar Hyperglycemic
D000078790	Insulin Secretion	Production and release of insulin from PANCREATIC BETA CELLS that primarily occurs in response to elevated BLOOD GLUCOSE levels.	Secretion, Insulin
D000657	Amoxapine	The N-demethylated derivative of the antipsychotic agent LOXAPINE that works by blocking the reuptake of norepinephrine, serotonin, or both; it also blocks dopamine receptors. Amoxapine is used for the treatment of depression.	2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine,Asendin,Asendis,CL-67,772,Demolox,Desmethylloxapine,Défanyl,CL 67,772,CL67,772