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Cells of the yeast Saccharomyces cerevisiae were subjected to a number of treatments which protracted S phase without proportional effects on growth processes. These treatments allowed steady-state exponential growth but lengthened the overall generation time. Such cells exhibited larger cell sizes and earlier performance of the cell cycle regulatory event 'start' and the two prereplicative steps defined by cdc4 and cdc7 mutations. Similarly, inhibiting progress through nuclear division with sub-arresting concentrations of methyl-benzimidazole-2-yl-carbamate also caused longer steady-state cell cycle times and earlier performance of 'start'. These findings underscore and extend earlier conclusions that most of the G1 interval of the yeast cell cycle is simply a period of ongoing growth. Conditions which protract any one of the periodic events in the division process without affecting growth will lead to the virtual elimination of the G1 interval.
G C Johnston, and
R A Singer
April 2014,
The Journal of toxicological sciences,
G C Johnston, and
R A Singer
October 1996,
FEMS microbiology letters,
G C Johnston, and
R A Singer
October 2014,
Bio-protocol,
G C Johnston, and
R A Singer
March 1977,
Experimental cell research,
G C Johnston, and
R A Singer
April 2004,
Proceedings of the National Academy of Sciences of the United States of America,
G C Johnston, and
R A Singer
August 1991,
Seminars in cell biology,
G C Johnston, and
R A Singer
January 1977,
Cytobios,
G C Johnston, and
R A Singer
January 1997,
Progress in cell cycle research,
G C Johnston, and
R A Singer
February 1982,
Genetics,
G C Johnston, and
R A Singer
January 1981,
Molecular & general genetics : MGG,
