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A randomized prospective double blind study of the analgesic effect of 75 mg intramuscular diclofenac sodium (Voltaren), a potent prostaglandin synthetase inhibitor, versus placebo (saline solution) was carried out in 131 consecutive patients with acute ureteral colic. Diclofenac provided complete relief of pain 25 minutes after the injection in 59% of the cases, while placebo provided relief in 29% (p less than 0.01). Forty patients in the placebo group and seventeen patients in the diclofenac group needed an open injection of 75 mg diclofenac intramuscularly after 25 minutes due to persistent pain. Fifty-four of the fifty-seven patients treated with an open injection of diclofenac achieved complete relief of pain after 30 minutes. There were no side-effects of the treatment.
A Vignoni, and
A Fierro, and
G Moreschini, and
M Cau, and
A Agostino, and
E Daniele, and
G Foti, and
E Grossi
January 1985,
Minerva urologica e nefrologica = The Italian journal of urology and nephrology,
A Vignoni, and
A Fierro, and
G Moreschini, and
M Cau, and
A Agostino, and
E Daniele, and
G Foti, and
E Grossi
April 1984,
British medical journal (Clinical research ed.),
A Vignoni, and
A Fierro, and
G Moreschini, and
M Cau, and
A Agostino, and
E Daniele, and
G Foti, and
E Grossi
January 2001,
International urology and nephrology,
A Vignoni, and
A Fierro, and
G Moreschini, and
M Cau, and
A Agostino, and
E Daniele, and
G Foti, and
E Grossi
January 1984,
The Journal of international medical research,
A Vignoni, and
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G Moreschini, and
M Cau, and
A Agostino, and
E Daniele, and
G Foti, and
E Grossi
January 1995,
European urology,
A Vignoni, and
A Fierro, and
G Moreschini, and
M Cau, and
A Agostino, and
E Daniele, and
G Foti, and
E Grossi
January 1985,
La Clinica terapeutica,
A Vignoni, and
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G Moreschini, and
M Cau, and
A Agostino, and
E Daniele, and
G Foti, and
E Grossi
October 1996,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
A Vignoni, and
A Fierro, and
G Moreschini, and
M Cau, and
A Agostino, and
E Daniele, and
G Foti, and
E Grossi
July 1997,
Gastroenterology,
A Vignoni, and
A Fierro, and
G Moreschini, and
M Cau, and
A Agostino, and
E Daniele, and
G Foti, and
E Grossi
January 1986,
Clinical therapeutics,
A Vignoni, and
A Fierro, and
G Moreschini, and
M Cau, and
A Agostino, and
E Daniele, and
G Foti, and
E Grossi
January 1979,
Rheumatology and rehabilitation,
