-transparent.png){kind=logo}
Somatomedins (SM) or insulin-like growth factors (IGF) constitute a heterogeneous group of peptides with important growth-promoting effects in vitro as well as in vivo. Amino acid sequences have been determined for only two of them, IGF-I and IGF-II, which are highly homologous. IGF-I, which is identical with SM-C, is composed of 70 amino acid residues and IGF-II contains 73 amino acids and may be identical with SM-A. Other peptides with different charge properties but with similar SM-like or insulin-like behaviour in biological and receptor assays, have been described but have not yet been fully characterized. The liver is known to be a major site of production of these peptides, but many other tissues--especially in the fetus--may synthesize them as well. We report here the nucleotide sequence of a human liver cDNA encoding the complete amino acid sequence of IGF-I. The IGF-I coding region is flanked by sequences encoding an amino-terminal peptide of at least 25 amino acid residues and a carboxyl-terminal peptide of 35 amino acids. This provides evidence that IGF-I is synthesized as a precursor protein and that formation of IGF-I from this precursor requires proteolytic processing at both ends.
M Jansen, and
F M van Schaik, and
A T Ricker, and
B Bullock, and
D E Woods, and
K H Gabbay, and
A L Nussbaum, and
J S Sussenbach, and
J L Van den Brande
August 1993,
Gene,
M Jansen, and
F M van Schaik, and
A T Ricker, and
B Bullock, and
D E Woods, and
K H Gabbay, and
A L Nussbaum, and
J S Sussenbach, and
J L Van den Brande
October 1986,
DNA (Mary Ann Liebert, Inc.),
M Jansen, and
F M van Schaik, and
A T Ricker, and
B Bullock, and
D E Woods, and
K H Gabbay, and
A L Nussbaum, and
J S Sussenbach, and
J L Van den Brande
January 1984,
Nature,
M Jansen, and
F M van Schaik, and
A T Ricker, and
B Bullock, and
D E Woods, and
K H Gabbay, and
A L Nussbaum, and
J S Sussenbach, and
J L Van den Brande
April 1986,
The Journal of biological chemistry,
M Jansen, and
F M van Schaik, and
A T Ricker, and
B Bullock, and
D E Woods, and
K H Gabbay, and
A L Nussbaum, and
J S Sussenbach, and
J L Van den Brande
January 1984,
Nature,
M Jansen, and
F M van Schaik, and
A T Ricker, and
B Bullock, and
D E Woods, and
K H Gabbay, and
A L Nussbaum, and
J S Sussenbach, and
J L Van den Brande
August 1987,
DNA (Mary Ann Liebert, Inc.),
M Jansen, and
F M van Schaik, and
A T Ricker, and
B Bullock, and
D E Woods, and
K H Gabbay, and
A L Nussbaum, and
J S Sussenbach, and
J L Van den Brande
January 1991,
Methods in enzymology,
M Jansen, and
F M van Schaik, and
A T Ricker, and
B Bullock, and
D E Woods, and
K H Gabbay, and
A L Nussbaum, and
J S Sussenbach, and
J L Van den Brande
January 1986,
Proceedings of the National Academy of Sciences of the United States of America,
M Jansen, and
F M van Schaik, and
A T Ricker, and
B Bullock, and
D E Woods, and
K H Gabbay, and
A L Nussbaum, and
J S Sussenbach, and
J L Van den Brande
October 1987,
FEBS letters,
M Jansen, and
F M van Schaik, and
A T Ricker, and
B Bullock, and
D E Woods, and
K H Gabbay, and
A L Nussbaum, and
J S Sussenbach, and
J L Van den Brande
November 1990,
Nucleic acids research,
