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The deleterious effects of aspirin on gastric mucosa have been well documented in experimental and clinical studies. Prostaglandins offer a potential method by which this injury may be prevented. In these studies, we developed a single-dose endoscopic assay system of aspirin-induced gastric mucosal injury in normal volunteers. With this system, 27 of 30 volunteers (90%) demonstrated severe mucosal injury after ingestion of aspirin. Subsequently, we evaluated whether pretreatment with 15-R-15 methyl prostaglandin E2 prevented severe injury after ingestion of aspirin. Following an initial dose-response study, a double-blind crossover trial was performed using pretreatment with placebo or with 10-micrograms doses of 15-R-15 methyl prostaglandin E2 for 24 h before treatment with aspirin. The results of this trial indicate that prostaglandin pretreatment significantly prevented the occurrence of endoscopically visible severe gastric mucosal injury after single-dose aspirin administration.
D A Gilbert, and
C M Surawicz, and
F E Silverstein, and
C R Weinberg, and
D R Saunders, and
A D Feld, and
R L Sanford, and
D Bergman, and
P Washington
October 1975,
Gut,
D A Gilbert, and
C M Surawicz, and
F E Silverstein, and
C R Weinberg, and
D R Saunders, and
A D Feld, and
R L Sanford, and
D Bergman, and
P Washington
December 1987,
The American journal of gastroenterology,
D A Gilbert, and
C M Surawicz, and
F E Silverstein, and
C R Weinberg, and
D R Saunders, and
A D Feld, and
R L Sanford, and
D Bergman, and
P Washington
January 1976,
Gut,
D A Gilbert, and
C M Surawicz, and
F E Silverstein, and
C R Weinberg, and
D R Saunders, and
A D Feld, and
R L Sanford, and
D Bergman, and
P Washington
January 1979,
The Journal of surgical research,
D A Gilbert, and
C M Surawicz, and
F E Silverstein, and
C R Weinberg, and
D R Saunders, and
A D Feld, and
R L Sanford, and
D Bergman, and
P Washington
September 1987,
The American journal of medicine,
D A Gilbert, and
C M Surawicz, and
F E Silverstein, and
C R Weinberg, and
D R Saunders, and
A D Feld, and
R L Sanford, and
D Bergman, and
P Washington
November 1979,
The American journal of gastroenterology,
D A Gilbert, and
C M Surawicz, and
F E Silverstein, and
C R Weinberg, and
D R Saunders, and
A D Feld, and
R L Sanford, and
D Bergman, and
P Washington
July 1976,
The Medical journal of Australia,
D A Gilbert, and
C M Surawicz, and
F E Silverstein, and
C R Weinberg, and
D R Saunders, and
A D Feld, and
R L Sanford, and
D Bergman, and
P Washington
March 1974,
Prostaglandins,
D A Gilbert, and
C M Surawicz, and
F E Silverstein, and
C R Weinberg, and
D R Saunders, and
A D Feld, and
R L Sanford, and
D Bergman, and
P Washington
February 1986,
Japanese journal of pharmacology,
D A Gilbert, and
C M Surawicz, and
F E Silverstein, and
C R Weinberg, and
D R Saunders, and
A D Feld, and
R L Sanford, and
D Bergman, and
P Washington
October 1973,
British medical journal,
