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To study the prevention of occlusion of aortocoronary-artery bypass grafts, we concluded a prospective, randomized, double-blind trial comparing long-term administration of dipyridamole (begun two days before operation) plus aspirin (begun seven hours after operation) with placebo in 407 patients. Results at one month showed a reduction in the rate of graft occlusion in patients receiving dipyridamole and aspirin. At vein-graft angiography performed in 343 patients (84 per cent) 11 to 18 months (median, 12 months) after operation, 11 per cent of 478 vein-graft distal anastomoses were occluded in the treated group, and 25 per cent of 486 were occluded in the placebo group. The proportion of patients with one or more distal anastomoses occluded was 22 per cent of 171 patients in the treated group and 47 per cent of 172 in the placebo group. All grafts were patent within a month of operation in 94 patients in the placebo group and 116 patients in the treated group; late development of occlusions was reduced from 27 per cent in the placebo group to 16 per cent in the treatment group. The results show that dipyridamole and aspirin continue to be effective in preventing vein-graft occlusion late after operation, and we believe that such treatment should be continued for at least one year.
J H Chesebro, and
V Fuster, and
L R Elveback, and
I P Clements, and
H C Smith, and
D R Holmes, and
W T Bardsley, and
J R Pluth, and
R B Wallace, and
F J Puga
January 1990,
Thrombosis research. Supplement,
J H Chesebro, and
V Fuster, and
L R Elveback, and
I P Clements, and
H C Smith, and
D R Holmes, and
W T Bardsley, and
J R Pluth, and
R B Wallace, and
F J Puga
March 2022,
Journal of cardiac surgery,
J H Chesebro, and
V Fuster, and
L R Elveback, and
I P Clements, and
H C Smith, and
D R Holmes, and
W T Bardsley, and
J R Pluth, and
R B Wallace, and
F J Puga
June 1984,
The New England journal of medicine,
J H Chesebro, and
V Fuster, and
L R Elveback, and
I P Clements, and
H C Smith, and
D R Holmes, and
W T Bardsley, and
J R Pluth, and
R B Wallace, and
F J Puga
May 2009,
The New England journal of medicine,
J H Chesebro, and
V Fuster, and
L R Elveback, and
I P Clements, and
H C Smith, and
D R Holmes, and
W T Bardsley, and
J R Pluth, and
R B Wallace, and
F J Puga
May 1991,
Circulation,
J H Chesebro, and
V Fuster, and
L R Elveback, and
I P Clements, and
H C Smith, and
D R Holmes, and
W T Bardsley, and
J R Pluth, and
R B Wallace, and
F J Puga
January 1998,
Coronary artery disease,
J H Chesebro, and
V Fuster, and
L R Elveback, and
I P Clements, and
H C Smith, and
D R Holmes, and
W T Bardsley, and
J R Pluth, and
R B Wallace, and
F J Puga
March 1981,
The Annals of thoracic surgery,
J H Chesebro, and
V Fuster, and
L R Elveback, and
I P Clements, and
H C Smith, and
D R Holmes, and
W T Bardsley, and
J R Pluth, and
R B Wallace, and
F J Puga
June 1983,
[Zasshi] [Journal]. Nihon Kyobu Geka Gakkai,
J H Chesebro, and
V Fuster, and
L R Elveback, and
I P Clements, and
H C Smith, and
D R Holmes, and
W T Bardsley, and
J R Pluth, and
R B Wallace, and
F J Puga
April 1994,
The Journal of thoracic and cardiovascular surgery,
J H Chesebro, and
V Fuster, and
L R Elveback, and
I P Clements, and
H C Smith, and
D R Holmes, and
W T Bardsley, and
J R Pluth, and
R B Wallace, and
F J Puga
September 2018,
Journal of thoracic disease,
