The uses and regional production of lead in ancient times are summarized. Since there is no evidence to suggest that any deliberate attempts were made to curtail personal exposure to the mine dusts or the emissions from the forges and crucibles, it is surmised that many of the ancient artisans who worked with lead probably contracted plumbism. The number of workers so exposed is estimated to be over 140,000 per year during the Roman Empire. The ancient literary records of work-related plumbism, however, are surprisingly sparse.