Biomaterial Database

Polyamine oxidase mediates intra-erythrocytic death of Plasmodium falciparum. 1983

A Ferrante, and C M Rzepczyk, and A C Allison

Using a number of established culture strains of Plasmodium falciparum, the effects of the addition of polyamine oxidase and spermine on the intra-erythrocytic forms were studied. Cultures to which polyamine oxidase and polyamines were added contained only degenerate parasites but if one or other were added alone the cultures were similar to the controls. The effects were confirmed by 35S-methionine incorporation.

UI	MeSH Term	Description	Entries
D008715	Methionine	A sulfur-containing essential L-amino acid that is important in many body functions.	L-Methionine,Liquimeth,Methionine, L-Isomer,Pedameth,L-Isomer Methionine,Methionine, L Isomer
D010963	Plasmodium falciparum	A species of protozoa that is the causal agent of falciparum malaria (MALARIA, FALCIPARUM). It is most prevalent in the tropics and subtropics.	Plasmodium falciparums,falciparums, Plasmodium
D004912	Erythrocytes	Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.	Blood Cells, Red,Blood Corpuscles, Red,Red Blood Cells,Red Blood Corpuscles,Blood Cell, Red,Blood Corpuscle, Red,Erythrocyte,Red Blood Cell,Red Blood Corpuscle
D000097667	Polyamine Oxidase	An FAD-dependent enzyme in the polyamine catabolism pathway that generates hydrogen peroxide. Present with high activity in most tissues of vertebrate organisms.	Aminoacetone Oxidase,N(1)-acetylpolyamine Oxidase,Non-Specific Polyamine Oxidase,Polyamine Oxidase (Propane-1,3-diamine-forming),Spermidine Oxidase,Spermine Oxidase
D000587	Oxidoreductases Acting on CH-NH Group Donors	Enzymes catalyzing the dehydrogenation of secondary amines, introducing a C	Secondary Amine Oxidoreductases,Amine Oxidoreductases, Secondary Amine,Amine Oxidoreductases, Secondary,Oxidoreductases Acting on CH NH Group Donors,Oxidoreductases, Secondary Amine
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013095	Spermidine	A polyamine formed from putrescine. It is found in almost all tissues in association with nucleic acids. It is found as a cation at all pH values, and is thought to help stabilize some membranes and nucleic acid structures. It is a precursor of spermine.
D013096	Spermine	A biogenic polyamine formed from spermidine. It is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria. It is found as a polycation at all pH values. Spermine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure.