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In previous studies we have demonstrated that the reduced renal reabsorption of calcium and hypercalciuria resulting from protein consumption are associated with serum insulin levels. Arginine stimulation of insulin secretion also results in hypercalciuria. The present study was designed to test whether the calciuria associated with arginine-stimulated insulin secretion is mediated by insulin inhibition of parathyroid hormone (PTH) activity. Parathyroidectomized (PTX) and sham-operated rats were infused with physiological saline, or with 12 mmol X kg-1 X hour-1 arginine in saline at 1.2 ml/hour. Analysis of data from clearance periods 90-150 minutes after infusions commenced show that arginine infusion increased urine volume, and calcium excretion (nanograms/minute and nanograms/milliliter glomerular filtration rate), to the same extent in PTX and sham-operated animals. PTH does not, therefore, appear to be involved in the calciuretic response to amino acid infusion.
C J Gollaher, and
R J Wood, and
M Holl, and
L H Allen
January 1986,
British journal of pharmacology,
C J Gollaher, and
R J Wood, and
M Holl, and
L H Allen
August 1983,
The American journal of clinical nutrition,
C J Gollaher, and
R J Wood, and
M Holl, and
L H Allen
May 1966,
Endocrinology,
C J Gollaher, and
R J Wood, and
M Holl, and
L H Allen
September 1982,
Journal of pharmacological methods,
C J Gollaher, and
R J Wood, and
M Holl, and
L H Allen
June 1988,
Toxicology and applied pharmacology,
C J Gollaher, and
R J Wood, and
M Holl, and
L H Allen
March 1971,
Israel journal of medical sciences,
C J Gollaher, and
R J Wood, and
M Holl, and
L H Allen
January 1973,
Toxicology and applied pharmacology,
C J Gollaher, and
R J Wood, and
M Holl, and
L H Allen
January 1982,
Chronobiologia,
C J Gollaher, and
R J Wood, and
M Holl, and
L H Allen
September 1976,
Blood,
C J Gollaher, and
R J Wood, and
M Holl, and
L H Allen
June 1978,
Endocrinology,
