BIOMAT Database Logo BIOMAT Database Logo

Heart transplantation. Four years' experience with conventional immunosuppression. 1984

J G Copeland, and R B Mammana, and J K Fuller, and D W Campbell, and M J McAleer, and J A Sailer

This article describes four years' experience with heart transplantation using conventional immunosuppression. Twenty of 32 patients are alive. The one-year survival rates were 75% (1979), 67% (1980), and 75% (1981). Actuarial survival rates for operative survivors were 70% at one year, 60% at two years, and 51% at three years. Patients in the 50- to 55-year age group have survived as well as younger recipients. Rejection resulted in six deaths, infection in three, donor heart failure in two, and multiple organ failure in one. There were 1.5 acute rejections per patient and one infection per patient in the first three posttransplant months. Postoperative hospital stay averaged 62 days and cost a total of $58,351.

UI MeSH Term Description Entries
D007165 Immunosuppression Therapy Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs. Antirejection Therapy,Immunosuppression,Immunosuppressive Therapy,Anti-Rejection Therapy,Therapy, Anti-Rejection,Therapy, Antirejection,Anti Rejection Therapy,Anti-Rejection Therapies,Antirejection Therapies,Immunosuppression Therapies,Immunosuppressions,Immunosuppressive Therapies,Therapies, Immunosuppression,Therapies, Immunosuppressive,Therapy, Immunosuppression,Therapy, Immunosuppressive
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009102 Multiple Organ Failure A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative. MODS,Multiple Organ Dysfunction Syndrome,Organ Dysfunction Syndrome, Multiple,Organ Failure, Multiple,Failure, Multiple Organ,Multiple Organ Failures
D009202 Cardiomyopathies A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS). Myocardial Disease,Myocardial Diseases,Myocardial Diseases, Primary,Myocardial Diseases, Secondary,Myocardiopathies,Primary Myocardial Disease,Cardiomyopathies, Primary,Cardiomyopathies, Secondary,Primary Myocardial Diseases,Secondary Myocardial Diseases,Cardiomyopathy,Cardiomyopathy, Primary,Cardiomyopathy, Secondary,Disease, Myocardial,Disease, Primary Myocardial,Disease, Secondary Myocardial,Diseases, Myocardial,Diseases, Primary Myocardial,Diseases, Secondary Myocardial,Myocardial Disease, Primary,Myocardial Disease, Secondary,Myocardiopathy,Primary Cardiomyopathies,Primary Cardiomyopathy,Secondary Cardiomyopathies,Secondary Cardiomyopathy,Secondary Myocardial Disease
D011182 Postoperative Care The period of care beginning when the patient is removed from surgery and aimed at meeting the patient's psychological and physical needs directly after surgery. (From Dictionary of Health Services Management, 2d ed) Care, Postoperative,Postoperative Procedures,Procedures, Postoperative,Postoperative Procedure,Procedure, Postoperative
D011183 Postoperative Complications Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery. Complication, Postoperative,Complications, Postoperative,Postoperative Complication
D011300 Preoperative Care Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed) Care, Preoperative,Preoperative Procedure,Preoperative Procedures,Procedure, Preoperative,Procedures, Preoperative
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D003524 Cyclosporins A group of closely related cyclic undecapeptides from the fungi Trichoderma polysporum and Cylindocarpon lucidum. They have some antineoplastic and antifungal action and significant immunosuppressive effects. Cyclosporins have been proposed as adjuvants in tissue and organ transplantation to suppress graft rejection. Cyclosporines
D006084 Graft Rejection An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient. Transplant Rejection,Rejection, Transplant,Transplantation Rejection,Graft Rejections,Rejection, Graft,Rejection, Transplantation,Rejections, Graft,Rejections, Transplant,Rejections, Transplantation,Transplant Rejections,Transplantation Rejections

Related Publications

J G Copeland, and R B Mammana, and J K Fuller, and D W Campbell, and M J McAleer, and J A Sailer
Heart transplantation after mechanical circulatory support: four years' experience.
January 1992, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation,
J G Copeland, and R B Mammana, and J K Fuller, and D W Campbell, and M J McAleer, and J A Sailer
Four years' experience with cadaveric renal transplantation.
March 1971, The New Zealand medical journal,
J G Copeland, and R B Mammana, and J K Fuller, and D W Campbell, and M J McAleer, and J A Sailer
Prospective study of everolimus with calcineurin inhibitor-free immunosuppression after heart transplantation: results at four years.
March 2014, The Annals of thoracic surgery,
J G Copeland, and R B Mammana, and J K Fuller, and D W Campbell, and M J McAleer, and J A Sailer
Ten years experience with belatacept-based immunosuppression after kidney transplantation.
April 2014, Journal of clinical medicine research,
J G Copeland, and R B Mammana, and J K Fuller, and D W Campbell, and M J McAleer, and J A Sailer
Review of four years experience with clinical heart transplantation at Stanford University Medical Center.
December 1972, Transplantation proceedings,
J G Copeland, and R B Mammana, and J K Fuller, and D W Campbell, and M J McAleer, and J A Sailer
Four years' experience with cyclosporin A in pediatric kidney transplantation.
January 1990, Acta paediatrica Scandinavica,
J G Copeland, and R B Mammana, and J K Fuller, and D W Campbell, and M J McAleer, and J A Sailer
Four years' experience with cyclosporine A in pediatric kidney transplantation.
June 1988, Transplantation proceedings,
J G Copeland, and R B Mammana, and J K Fuller, and D W Campbell, and M J McAleer, and J A Sailer
[Triple immunosuppression in renal transplantation in children: 3 years' experience].
January 1989, Pediatrie,
J G Copeland, and R B Mammana, and J K Fuller, and D W Campbell, and M J McAleer, and J A Sailer
Kidney transplantation in diabetic nephropathy: four years experience.
January 1977, Scandinavian journal of urology and nephrology. Supplementum,
J G Copeland, and R B Mammana, and J K Fuller, and D W Campbell, and M J McAleer, and J A Sailer
Three years' experience with heart and heart-lung transplantation in Norway.
June 1988, Transplantation proceedings,
Copied contents to your clipboard!