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An experimental radioisotopic study in normotensive male Wistar rats and spontaneously-hypertensive rats (SHR) of Okamoto--Aoki line demonstrated an age-related increase in the biosynthesis of prostacycline (PGI2) from 14C-arachidonic acid by pulmonary and aortal tissues of animals with normal arterial pressure. In SHRs, PGI2 production by lung homogenates did not change essentially with age, but decreased considerably in adult SHRs with stable hypertension. PGI2 biosynthesis by SHR's aortal tissue decreased with age and dropped significantly as arterial hypertension developed. In normotensive rats, the formation of thromboxane B2 (TxB2) by platelets increased with age. Platelet TxB2 biosynthesis was elevated considerably both in young and adult SHRs. Clinically, a significant increase of platelet TxB2 production from exogenous 14C-arachidonic acid was demonstrated in children with essential hypertension.
N V Mandrovnaia, and
Kh M Markov, and
I E Smirnov, and
I P Briazgunov
May 1990,
Hypertension (Dallas, Tex. : 1979),
N V Mandrovnaia, and
Kh M Markov, and
I E Smirnov, and
I P Briazgunov
March 1987,
Vrachebnoe delo,
N V Mandrovnaia, and
Kh M Markov, and
I E Smirnov, and
I P Briazgunov
December 1994,
The American journal of clinical nutrition,
N V Mandrovnaia, and
Kh M Markov, and
I E Smirnov, and
I P Briazgunov
September 1982,
Lipids,
N V Mandrovnaia, and
Kh M Markov, and
I E Smirnov, and
I P Briazgunov
December 1990,
Clinical and investigative medicine. Medecine clinique et experimentale,
N V Mandrovnaia, and
Kh M Markov, and
I E Smirnov, and
I P Briazgunov
April 1984,
Prostaglandins,
N V Mandrovnaia, and
Kh M Markov, and
I E Smirnov, and
I P Briazgunov
January 1991,
Advances in prostaglandin, thromboxane, and leukotriene research,
N V Mandrovnaia, and
Kh M Markov, and
I E Smirnov, and
I P Briazgunov
June 1988,
Proceedings of the National Academy of Sciences of the United States of America,
N V Mandrovnaia, and
Kh M Markov, and
I E Smirnov, and
I P Briazgunov
January 1983,
Advances in prostaglandin, thromboxane, and leukotriene research,
N V Mandrovnaia, and
Kh M Markov, and
I E Smirnov, and
I P Briazgunov
December 1988,
Chinese medical journal,
