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Timolol, a non-cardioselective beta-blocking agent, was administered orally after 2 weeks of placebo to 14 patients with essential hypertension for 8 weeks following 1-4 weeks of dose-ranging period. Patients were first hospitalized and submitted to a diagnostic workup. They were placed on a diet containing 100 mEq of Na+ and 65 mEq of K+; this regimen was also prescribed during outpatient treatment. The changes in blood pressure, systemic hemodynamics, plasma renin activity, urine aldosterone, and glomerular filtration rate were evaluated. A significant and stable decrease in systolic and diastolic blood pressure associated with a fall in cardiac output (-21%), heart rate (-17%), plasma renin activity, and urine aldosterone were observed. The blood pressure lowering effect was unrelated to the decrease in cardiac output and plasma renin activity. Glomerular filtration rate was unchanged. No important side effects were observed during the treatment.
E Valvo, and
L Gammaro, and
N Tessitore, and
A Fabris, and
V Ortalda, and
V Bedogna, and
G Maschio
September 1989,
Angiology,
E Valvo, and
L Gammaro, and
N Tessitore, and
A Fabris, and
V Ortalda, and
V Bedogna, and
G Maschio
February 1992,
Angiology,
E Valvo, and
L Gammaro, and
N Tessitore, and
A Fabris, and
V Ortalda, and
V Bedogna, and
G Maschio
December 1976,
Clinical science and molecular medicine. Supplement,
E Valvo, and
L Gammaro, and
N Tessitore, and
A Fabris, and
V Ortalda, and
V Bedogna, and
G Maschio
January 1979,
Acta medica Scandinavica. Supplementum,
E Valvo, and
L Gammaro, and
N Tessitore, and
A Fabris, and
V Ortalda, and
V Bedogna, and
G Maschio
January 1980,
Postgraduate medical journal,
E Valvo, and
L Gammaro, and
N Tessitore, and
A Fabris, and
V Ortalda, and
V Bedogna, and
G Maschio
August 1980,
Endocrinologia japonica,
E Valvo, and
L Gammaro, and
N Tessitore, and
A Fabris, and
V Ortalda, and
V Bedogna, and
G Maschio
September 1976,
Lancet (London, England),
E Valvo, and
L Gammaro, and
N Tessitore, and
A Fabris, and
V Ortalda, and
V Bedogna, and
G Maschio
September 1982,
Japanese circulation journal,
E Valvo, and
L Gammaro, and
N Tessitore, and
A Fabris, and
V Ortalda, and
V Bedogna, and
G Maschio
January 1980,
Clinical and experimental hypertension,
E Valvo, and
L Gammaro, and
N Tessitore, and
A Fabris, and
V Ortalda, and
V Bedogna, and
G Maschio
May 1983,
Kokyu to junkan. Respiration & circulation,
