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This study demonstrates that increased collagen production but not an altered ratio of type III:I collagen is associated with breast capsular contracture. From these findings and previous data, therefore, it appears that capsular contracture is associated with increased foreign-body response biochemically as well as histologically. Further studies are required to directly assess the reasons for contraction around some implants and not others; however, it appears that control of capsular contracture may be achieved by controlling biochemical as well as cellular events associated with contraction. Such studies remain to be done.
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