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The extracellular lining of the lungs is reviewed. The pulmonary extracellular lining is a complex mixture of phospholipids, proteins and carbohydrates which is absolutely essential for the maintenance of normal pulmonary functions such as gas exchange. Without the lining the lungs would collapse. Alterations in the pulmonary extracellular lining may underlie some disease conditions induced by toxic agents, especially those which interfere with the formation of pulmonary surfactant. The extracellular lining could be used to detect and monitor damage and disease caused by agents toxic to the lungs. The lining contains many hydrolytic enzymes which may act to detoxify certain toxic agents such as those which contain ester groups. The pulmonary extracellular lining could play a significant role mediating the toxic action of inhaled agents as well as the removal of those agents from the lungs.
G George, and
G E Hook
August 1977,
Pneumonologia polska,
G George, and
G E Hook
January 1971,
Acta Universitatis Carolinae. Medica,
G George, and
G E Hook
June 1948,
Archives of pathology,
G George, and
G E Hook
January 1971,
Uspekhi sovremennoi biologii,
G George, and
G E Hook
October 1987,
The American review of respiratory disease,
G George, and
G E Hook
September 1968,
The American review of respiratory disease,
G George, and
G E Hook
January 1977,
Acta medica Polona,
G George, and
G E Hook
January 1976,
Pathologia Europaea,
G George, and
G E Hook
December 1987,
The Biochemical journal,
