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The plasma glucose, C-peptide and insulin responses to subcutaneously administered highly purified porcine, 'semi-synthetic' and 'biosynthetic' human isophane (NPH) insulin and diluting medium as control in normal male subjects were evaluated. Porcine and semi-synthetic human NPH insulins were administered at two dose levels of 0.15 and 0.30 U/kg body weight and biosynthetic human NPH at 0.15 U/kg body weight only. At the low dose level the three insulin preparations resulted in a similar maximal hypoglycaemic effect within 3-5 h after administration. However, over the remainder of the 11 h post-injection period, the plasma glucose level was lower after semi-synthetic human insulin. In contrast, at the 0.30 U/kg dose level, there was no difference in the early or late hypoglycaemic response between porcine and semi-synthetic human NPH insulins of equivalent pharmaceutical formulation. The clinical relevance of these findings needs further evaluation. The data suggest that for the 'intermediate-acting' NPH insulin preparations, both the species of insulin, nature and quantity of the retarding protein and their subsequent interaction may determine their time-action characteristics.
D R Owens, and
I R Jones, and
A J Birtwell, and
C T Burge, and
S Luzio, and
C J Davies, and
P Heyburn, and
L G Heding
January 1984,
Acta medica Scandinavica,
D R Owens, and
I R Jones, and
A J Birtwell, and
C T Burge, and
S Luzio, and
C J Davies, and
P Heyburn, and
L G Heding
January 1987,
European journal of clinical pharmacology,
D R Owens, and
I R Jones, and
A J Birtwell, and
C T Burge, and
S Luzio, and
C J Davies, and
P Heyburn, and
L G Heding
January 1987,
Domestic animal endocrinology,
D R Owens, and
I R Jones, and
A J Birtwell, and
C T Burge, and
S Luzio, and
C J Davies, and
P Heyburn, and
L G Heding
January 1981,
Diabetes care,
D R Owens, and
I R Jones, and
A J Birtwell, and
C T Burge, and
S Luzio, and
C J Davies, and
P Heyburn, and
L G Heding
January 1998,
Diabetologia,
D R Owens, and
I R Jones, and
A J Birtwell, and
C T Burge, and
S Luzio, and
C J Davies, and
P Heyburn, and
L G Heding
January 1989,
Diabetic medicine : a journal of the British Diabetic Association,
D R Owens, and
I R Jones, and
A J Birtwell, and
C T Burge, and
S Luzio, and
C J Davies, and
P Heyburn, and
L G Heding
July 1982,
British medical journal (Clinical research ed.),
D R Owens, and
I R Jones, and
A J Birtwell, and
C T Burge, and
S Luzio, and
C J Davies, and
P Heyburn, and
L G Heding
May 1993,
Diabetes research and clinical practice,
D R Owens, and
I R Jones, and
A J Birtwell, and
C T Burge, and
S Luzio, and
C J Davies, and
P Heyburn, and
L G Heding
February 1984,
Acta endocrinologica,
D R Owens, and
I R Jones, and
A J Birtwell, and
C T Burge, and
S Luzio, and
C J Davies, and
P Heyburn, and
L G Heding
January 1984,
Acta diabetologica latina,
