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Four types of human breast lesions and C3H mouse mammary adenocarcinomas (type A) were examined for the immunocytochemical localization of cells containing hormone-like substances. Insulin- or somatostatin-like immunoreactive material was observed in scattered single cells and nests of tumor cells in seven of eight infiltrating duct carcinomas, and in the majority of tumor cells from an anaplastic carcinoma. A few somatostatin-immunoreactive cells were observed in only one of seven fibroadenomas studied. No immunoreactive cells were observed in mouse adenocarcinomas or in human breast dysplasias. These results suggest that cells with hormone-like immunoreactivity may be a common feature in two types of malignant human breast tumors.
E J Spring-Mills, and
S B Stearns, and
P J Numann, and
P H Smith
January 1986,
Peptides,
E J Spring-Mills, and
S B Stearns, and
P J Numann, and
P H Smith
June 1983,
No to shinkei = Brain and nerve,
E J Spring-Mills, and
S B Stearns, and
P J Numann, and
P H Smith
November 1986,
Biology of reproduction,
E J Spring-Mills, and
S B Stearns, and
P J Numann, and
P H Smith
September 1994,
Annals of the New York Academy of Sciences,
E J Spring-Mills, and
S B Stearns, and
P J Numann, and
P H Smith
July 1998,
The American journal of pathology,
E J Spring-Mills, and
S B Stearns, and
P J Numann, and
P H Smith
November 1988,
Cancer research,
E J Spring-Mills, and
S B Stearns, and
P J Numann, and
P H Smith
July 1976,
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society,
E J Spring-Mills, and
S B Stearns, and
P J Numann, and
P H Smith
March 1985,
Brain research,
E J Spring-Mills, and
S B Stearns, and
P J Numann, and
P H Smith
October 1980,
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E J Spring-Mills, and
S B Stearns, and
P J Numann, and
P H Smith
July 1978,
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society,
