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Defective recovery from insulin-induced hypoglycemia, due to combined deficiencies of glucagon and epinephrine secretory responses to plasma glucose decrements, occurs in some patients with insulin-dependent diabetes mellitus (IDDM). Patients with IDDM determined to have inadequate glucose counterregulation during an insulin infusion test (40 mU X kg-1 X h-1) with bedside plasma glucose monitoring and clinical observation have been found to have a 25-fold greater risk of severe hypoglycemia during subsequent intensive therapy than patients with adequate glucose counterregulation. Thus, the efficacy of the glucose counterregulatory systems determines the limits of intensive therapy of IDDM.
J V Santiago, and
N H White, and
D A Skor, and
L A Levandoski, and
D M Bier, and
P E Cryer
July 1985,
The New England journal of medicine,
J V Santiago, and
N H White, and
D A Skor, and
L A Levandoski, and
D M Bier, and
P E Cryer
March 1986,
The New England journal of medicine,
J V Santiago, and
N H White, and
D A Skor, and
L A Levandoski, and
D M Bier, and
P E Cryer
May 1987,
The New England journal of medicine,
J V Santiago, and
N H White, and
D A Skor, and
L A Levandoski, and
D M Bier, and
P E Cryer
July 2001,
Diabetic medicine : a journal of the British Diabetic Association,
J V Santiago, and
N H White, and
D A Skor, and
L A Levandoski, and
D M Bier, and
P E Cryer
October 1984,
The New England journal of medicine,
J V Santiago, and
N H White, and
D A Skor, and
L A Levandoski, and
D M Bier, and
P E Cryer
April 1982,
The Journal of laboratory and clinical medicine,
J V Santiago, and
N H White, and
D A Skor, and
L A Levandoski, and
D M Bier, and
P E Cryer
December 1988,
Diabetes,
J V Santiago, and
N H White, and
D A Skor, and
L A Levandoski, and
D M Bier, and
P E Cryer
June 1984,
The New England journal of medicine,
J V Santiago, and
N H White, and
D A Skor, and
L A Levandoski, and
D M Bier, and
P E Cryer
January 1990,
Hormone and metabolic research. Supplement series,
J V Santiago, and
N H White, and
D A Skor, and
L A Levandoski, and
D M Bier, and
P E Cryer
April 1980,
Prostaglandins and medicine,
