Updating the Goeckerman regimen for psoriasis. 1978

J W Petrozzi, and J O Barton, and K K Kaidbey, and A M Kligman

Various components of the Goeckerman regimen were analysed. Although our findings are preliminary, they indicate several important observations: (1) Irradiation of tar treated patients with UVA compared to UVB showed the most efficacious wavelengths to be in the erythemic range (UVB). (2) A 1% concentration of crude coal tar was as effective as 5 and 25%.(3) Application of tar 2 h prior to irradiation was equivalent to overnight usage. (4) Little difference was noted between hydrophilic ointment and petrolatum as vehicles. (5) A tar gel was less beneficial than crude tar. The benefits of the Goeckerman therapy are derived from the intrinsic antipsoriatic effects of both tar and UVB. For some the combination is additive and necessary for clearing; for others either of the components may have great benefit alone. Our favourable results with UVB alone indicate that its effectiveness has been understated and poorly appreciated. Minimizing the time of tar application without loss of efficacy makes treatment adaptable to outpatient practice.

UI MeSH Term Description Entries
D011565 Psoriasis A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis. Palmoplantaris Pustulosis,Pustular Psoriasis of Palms and Soles,Pustulosis Palmaris et Plantaris,Pustulosis of Palms and Soles,Psoriases
D003033 Coal Tar A by-product of the destructive distillation of coal used as a topical antieczematic. It is an antipruritic and keratoplastic agent used also in the treatment of psoriasis and other skin conditions. Occupational exposure to soots, tars, and certain mineral oils is known to be carcinogenic according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985) (Merck Index, 11th ed). Clinitar,Estar,Tar, Coal
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor
D014467 Ultraviolet Therapy The use of ultraviolet electromagnetic radiation in the treatment of disease, usually of the skin. This is the part of the sun's spectrum that causes sunburn and tanning. Ultraviolet A, used in PUVA, is closer to visible light and less damaging than Ultraviolet B, which is ionizing. Actinotherapy,Therapy, Ultraviolet,Actinotherapies,Therapies, Ultraviolet,Ultraviolet Therapies
D014677 Pharmaceutical Vehicles A carrier or inert medium used as a solvent (or diluent) in which the medicinally active agent is formulated and or administered. (Dictionary of Pharmacy, 1986) Pharmaceutical Vehicle,Vehicle, Pharmaceutical,Vehicles, Pharmaceutical

Related Publications

J W Petrozzi, and J O Barton, and K K Kaidbey, and A M Kligman
October 2006, Archives of dermatological research,
J W Petrozzi, and J O Barton, and K K Kaidbey, and A M Kligman
July 2013, Journal of visualized experiments : JoVE,
J W Petrozzi, and J O Barton, and K K Kaidbey, and A M Kligman
July 1983, Journal of the American Academy of Dermatology,
J W Petrozzi, and J O Barton, and K K Kaidbey, and A M Kligman
February 1980, Cutis,
J W Petrozzi, and J O Barton, and K K Kaidbey, and A M Kligman
August 1979, The Journal of investigative dermatology,
J W Petrozzi, and J O Barton, and K K Kaidbey, and A M Kligman
January 2009, Pediatric dermatology,
J W Petrozzi, and J O Barton, and K K Kaidbey, and A M Kligman
August 1968, Archives of dermatology,
J W Petrozzi, and J O Barton, and K K Kaidbey, and A M Kligman
May 1981, Journal of the American Academy of Dermatology,
J W Petrozzi, and J O Barton, and K K Kaidbey, and A M Kligman
January 2021, Acta medica (Hradec Kralove),
J W Petrozzi, and J O Barton, and K K Kaidbey, and A M Kligman
October 2013, Journal of the American Academy of Dermatology,
Copied contents to your clipboard!