Differential blood cell separation using a high gradient magnetic field. 1978

F Paul, and S Roath, and D Melville

A technique for the separation of erythrocytes from whole blood is described which exploits the magnetic property of haemoglobin in the reduced state. The technique is characterized by the use of a filter consisting of a cylinder, containing stainless steel wire mesh, placed between the jaws of an electro magnet. When activated, the electromagnet induces a magnetic field gradient in the vicinity of each of the constituent wires, sufficient to attract and trap erythrocytes in suspension. The number of erythrocytes captured varies with the applied field (0-1.4 Tesla in these experiments) and flow rate (1.9-12.9 x 10(-4) m s-1). The capture process does not cause haemolysis or observable surface damage to the erythrocytes and neither leucocytes nor platelets are retained by the filter.

UI MeSH Term Description Entries
D008280 Magnetics The study of MAGNETIC PHENOMENA. Magnetic
D002469 Cell Separation Techniques for separating distinct populations of cells. Cell Isolation,Cell Segregation,Isolation, Cell,Cell Isolations,Cell Segregations,Cell Separations,Isolations, Cell,Segregation, Cell,Segregations, Cell,Separation, Cell,Separations, Cell
D004906 Erythrocyte Count The number of RED BLOOD CELLS per unit volume in a sample of venous BLOOD. Blood Cell Count, Red,Erythrocyte Number,Red Blood Cell Count,Count, Erythrocyte,Counts, Erythrocyte,Erythrocyte Counts,Erythrocyte Numbers
D004912 Erythrocytes Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN. Blood Cells, Red,Blood Corpuscles, Red,Red Blood Cells,Red Blood Corpuscles,Blood Cell, Red,Blood Corpuscle, Red,Erythrocyte,Red Blood Cell,Red Blood Corpuscle

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