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The effects of a 48 h infusion of arginine vasopressin (AVP) were measured in five separate studies on four normal salt-restricted physicians, in whom fluid retention was prevented. The infusion was associated with an increase in renal sodium excretion which continued during the 24 h after the infusion had been discontinued. During the infusion plasma renin activity (PRA), plasma aldosterone and noradrenaline, and packed cell volume (PCV) fell; glomerular filtration rate, assessed by endogenous creatinine clearance, increased. The findings are best explained by a vasopressin-induced increase in plasma volume, which in the absence of fluid retention is likely to have been due to a redistribution of body water.
P J Drew, and
J N Barnes, and
J M Holly, and
A Knight, and
F J Goodwin
July 1985,
The American journal of physiology,
P J Drew, and
J N Barnes, and
J M Holly, and
A Knight, and
F J Goodwin
December 1986,
The Journal of endocrinology,
P J Drew, and
J N Barnes, and
J M Holly, and
A Knight, and
F J Goodwin
May 1989,
Journal of endocrinological investigation,
P J Drew, and
J N Barnes, and
J M Holly, and
A Knight, and
F J Goodwin
January 1947,
British medical bulletin,
P J Drew, and
J N Barnes, and
J M Holly, and
A Knight, and
F J Goodwin
January 1985,
European journal of applied physiology and occupational physiology,
P J Drew, and
J N Barnes, and
J M Holly, and
A Knight, and
F J Goodwin
January 1988,
Journal of applied physiology (Bethesda, Md. : 1985),
P J Drew, and
J N Barnes, and
J M Holly, and
A Knight, and
F J Goodwin
January 1987,
Annals of clinical and laboratory science,
P J Drew, and
J N Barnes, and
J M Holly, and
A Knight, and
F J Goodwin
July 1961,
Schweizerische medizinische Wochenschrift,
P J Drew, and
J N Barnes, and
J M Holly, and
A Knight, and
F J Goodwin
January 1971,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
P J Drew, and
J N Barnes, and
J M Holly, and
A Knight, and
F J Goodwin
October 1986,
British journal of clinical pharmacology,
