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A human IgG preparation was given intravenously to 36 newborn infants admitted to the neonatal intensive care unit because of suspected septicaemia. IgG was given as a single dose of 0.4 g/kg body weight. Patient serum was obtained immediately before and 30 min after terminating the infusion. Blood was also withdrawn 2 days after giving the IgG in eight of the infants. The sera were tested by radioimmunoassay for IgG antibody levels to surface antigens of group B streptococci (GBS) types Ia, Ib, II and III and to R-protein. The mean increases in anti-type Ia, Ib, II, III and R-protein antibodies 30 min after the end of infusion were 81%, 73%, 49%, 60% and 69% of the preinfusion levels, respectively. This was followed by a rapid decrease during the following 2 days to 25%-32% of the initial increases. Based on the above findings, a controlled trial of passive immunisation in the management of neonatal GBS septicaemia seems justified. The rapid decline in antibody levels would necessitate a second infusion 24 h after the initial immunoglobulin administration if the suspicion of septicaemia persists.
K K Christensen, and
P Christensen, and
H U Bucher, and
G Duc, and
C H Kind, and
D Mieth, and
B Müller, and
R A Seger
September 1994,
The Journal of infectious diseases,
K K Christensen, and
P Christensen, and
H U Bucher, and
G Duc, and
C H Kind, and
D Mieth, and
B Müller, and
R A Seger
October 1989,
Pediatric research,
K K Christensen, and
P Christensen, and
H U Bucher, and
G Duc, and
C H Kind, and
D Mieth, and
B Müller, and
R A Seger
January 1976,
Zentralblatt fur Gynakologie,
K K Christensen, and
P Christensen, and
H U Bucher, and
G Duc, and
C H Kind, and
D Mieth, and
B Müller, and
R A Seger
January 1981,
Transactions of the Royal Society of Tropical Medicine and Hygiene,
K K Christensen, and
P Christensen, and
H U Bucher, and
G Duc, and
C H Kind, and
D Mieth, and
B Müller, and
R A Seger
March 1977,
Lancet (London, England),
K K Christensen, and
P Christensen, and
H U Bucher, and
G Duc, and
C H Kind, and
D Mieth, and
B Müller, and
R A Seger
March 1977,
Lancet (London, England),
K K Christensen, and
P Christensen, and
H U Bucher, and
G Duc, and
C H Kind, and
D Mieth, and
B Müller, and
R A Seger
May 1977,
Lancet (London, England),
K K Christensen, and
P Christensen, and
H U Bucher, and
G Duc, and
C H Kind, and
D Mieth, and
B Müller, and
R A Seger
March 2003,
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases,
K K Christensen, and
P Christensen, and
H U Bucher, and
G Duc, and
C H Kind, and
D Mieth, and
B Müller, and
R A Seger
July 1978,
Medizinische Klinik,
K K Christensen, and
P Christensen, and
H U Bucher, and
G Duc, and
C H Kind, and
D Mieth, and
B Müller, and
R A Seger
January 2001,
Indian journal of medical microbiology,
