Spatial analysis of evoked potentials in man--a review. 1984

D Lehmann, and W Skrandies

Steps in brain information processing are reflected on the scalp as changes of the electric potential which is evoked by the stimulus. However, for a given recording point on the scalp, there is no absolute amplitude or phase information of the electric brain potential. This means that the shape of an evoked potential waveform which is recorded from a given scalp location crucially depends on the location of the chosen reference. Only unbiased results of evoked potential data evaluation can be hoped to elucidate or map successfully into information processing models established by other methods, e.g. behavior measurements. Conventional recordings vs a common reference contain only one of many possible sets of waveshapes. In order to avoid ambiguities or bias of results, the entire evoked potential data set firstly must be analysed over space, and reference-independent parameters must be extracted. For each time point, the spatial distribution of the potentials is viewed as field map. The parameter extraction in a direct approach at each time point includes, e.g. locations of field peaks and troughs, voltage and gradient between them, and global electrical field power; or, parameters via the first or second spatial derivative of the electric field. In the second step, changes of these reference-independent field measurements are analysed over time. At component latency which is defined by maximal, global field power or by voltage range, mapped field distributions can be compared using maximal/minimal field value locations or complete maps. Significantly different field configurations establish the activity of non-identical neural generators. Classification of the field configurations (examination of orbits of field extrema over time) leads to the segmentation of series of field maps (multichannel EP data) into short epochs of stationary spatial configurations (i.e. spatially characterized components) with equal consideration of all recording points, and without the amplitude criterion. The application of these principles to the following problems is discussed: comparison of evoked potentials between different analysis times, in particular pre-stimulus and post-stimulus electric brain states; zero baseline for measurement; reference electrode; identification of evoked components in time and space. Illustrations of these problems include functional differences of input-analysing sub-systems, and the topography of cognition- and speech-related electric brain activity.

UI MeSH Term Description Entries
D011601 Psychophysics The science dealing with the correlation of the physical characteristics of a stimulus, e.g., frequency or intensity, with the response to the stimulus, in order to assess the psychologic factors involved in the relationship. Psychophysic
D012160 Retina The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent. Ora Serrata
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D001931 Brain Mapping Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures. Brain Electrical Activity Mapping,Functional Cerebral Localization,Topographic Brain Mapping,Brain Mapping, Topographic,Functional Cerebral Localizations,Mapping, Brain,Mapping, Topographic Brain
D003071 Cognition Intellectual or mental process whereby an organism obtains knowledge. Cognitive Function,Cognitions,Cognitive Functions,Function, Cognitive,Functions, Cognitive
D005071 Evoked Potentials Electrical responses recorded from nerve, muscle, SENSORY RECEPTOR, or area of the CENTRAL NERVOUS SYSTEM following stimulation. They range from less than a microvolt to several microvolts. The evoked potential can be auditory (EVOKED POTENTIALS, AUDITORY), somatosensory (EVOKED POTENTIALS, SOMATOSENSORY), visual (EVOKED POTENTIALS, VISUAL), or motor (EVOKED POTENTIALS, MOTOR), or other modalities that have been reported. Event Related Potential,Event-Related Potentials,Evoked Potential,N100 Evoked Potential,P50 Evoked Potential,N1 Wave,N100 Evoked Potentials,N2 Wave,N200 Evoked Potentials,N3 Wave,N300 Evoked Potentials,N4 Wave,N400 Evoked Potentials,P2 Wave,P200 Evoked Potentials,P50 Evoked Potentials,P50 Wave,P600 Evoked Potentials,Potentials, Event-Related,Event Related Potentials,Event-Related Potential,Evoked Potential, N100,Evoked Potential, N200,Evoked Potential, N300,Evoked Potential, N400,Evoked Potential, P200,Evoked Potential, P50,Evoked Potential, P600,Evoked Potentials, N100,Evoked Potentials, N200,Evoked Potentials, N300,Evoked Potentials, N400,Evoked Potentials, P200,Evoked Potentials, P50,Evoked Potentials, P600,N1 Waves,N2 Waves,N200 Evoked Potential,N3 Waves,N300 Evoked Potential,N4 Waves,N400 Evoked Potential,P2 Waves,P200 Evoked Potential,P50 Waves,P600 Evoked Potential,Potential, Event Related,Potential, Event-Related,Potential, Evoked,Potentials, Event Related,Potentials, Evoked,Potentials, N400 Evoked,Related Potential, Event,Related Potentials, Event,Wave, N1,Wave, N2,Wave, N3,Wave, N4,Wave, P2,Wave, P50,Waves, N1,Waves, N2,Waves, N3,Waves, N4,Waves, P2,Waves, P50
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

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