-transparent.png){kind=logo}
Male and female rats (20 of each sex) were killed, and a broad sample of organs were excised, weighed, and immersed in 10% neutral buffered formalin. Following 72 hours fixation the organs were reweighed. Comparison of fresh and fixed organ weights revealed statistically significant organ weight changes due to fixation. Although the fixation-induced organ weight changes varied in both direction and magnitude among organs and between sexes, the changes were consistent throughout samplings of each specific organ. The results of this study therefore suggest that fixed organ weights may be a valid alternative to fresh organ weights. A significantly larger data base must be generated, however, to determine the influence of fixation prior to weighing in the presence of the various pathologic tissue alterations observed in safety evaluation studies.
R L Kanerva, and
F R Lefever, and
C L Alden
January 1973,
Biology of the neonate,
R L Kanerva, and
F R Lefever, and
C L Alden
January 1974,
Zeitschrift fur Versuchstierkunde,
R L Kanerva, and
F R Lefever, and
C L Alden
September 1966,
Growth,
R L Kanerva, and
F R Lefever, and
C L Alden
March 1976,
Toxicology and applied pharmacology,
R L Kanerva, and
F R Lefever, and
C L Alden
June 2012,
Journal of medical primatology,
R L Kanerva, and
F R Lefever, and
C L Alden
February 1972,
Endokrinologie,
R L Kanerva, and
F R Lefever, and
C L Alden
January 1967,
Toxicology and applied pharmacology,
R L Kanerva, and
F R Lefever, and
C L Alden
March 1960,
Journal of the National Cancer Institute,
R L Kanerva, and
F R Lefever, and
C L Alden
March 1966,
Growth,
R L Kanerva, and
F R Lefever, and
C L Alden
January 2005,
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society,
