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A randomized four-way crossover study was carried out in 12 healthy volunteers to investigate the pharmacokinetics of a new oral combination of frusemide (40 mg) and amiloride (5 mg), formulated as a single tablet. The experimental design of this bioequivalence study used commercially-available 40 mg frusemide tablets and 5 mg amiloride tablets as reference drugs, administered either separately or concomitantly. From a statistical analysis of plasma levels of frusemide and amiloride, no significant differences between the reference drugs alone and the combination tablet were seen in peak plasma levels, mean times to peak or mean areas under the plasma concentration-time curves (AUCs). The ratio of AUCs of the combination tablet to the reference drugs approached a limiting value many hours prior to complete elimination of the drug and hence reliable bioavailability comparisons were possible with blood sampling up to 24 hours post-dose.
S G Brooks, and
R B Christie, and
J Roche, and
A P Fairhead, and
D Muirhead, and
H A Townsend, and
H L Shaw
June 1985,
British journal of clinical practice. Supplement,
S G Brooks, and
R B Christie, and
J Roche, and
A P Fairhead, and
D Muirhead, and
H A Townsend, and
H L Shaw
May 2010,
Indian journal of pharmaceutical sciences,
S G Brooks, and
R B Christie, and
J Roche, and
A P Fairhead, and
D Muirhead, and
H A Townsend, and
H L Shaw
January 1984,
Current medical research and opinion,
S G Brooks, and
R B Christie, and
J Roche, and
A P Fairhead, and
D Muirhead, and
H A Townsend, and
H L Shaw
January 1984,
Current medical research and opinion,
S G Brooks, and
R B Christie, and
J Roche, and
A P Fairhead, and
D Muirhead, and
H A Townsend, and
H L Shaw
January 1990,
The Journal of international medical research,
S G Brooks, and
R B Christie, and
J Roche, and
A P Fairhead, and
D Muirhead, and
H A Townsend, and
H L Shaw
November 1987,
Archives internationales de pharmacodynamie et de therapie,
S G Brooks, and
R B Christie, and
J Roche, and
A P Fairhead, and
D Muirhead, and
H A Townsend, and
H L Shaw
June 1997,
Journal of chromatography. B, Biomedical sciences and applications,
S G Brooks, and
R B Christie, and
J Roche, and
A P Fairhead, and
D Muirhead, and
H A Townsend, and
H L Shaw
January 1979,
Clinical pharmacokinetics,
S G Brooks, and
R B Christie, and
J Roche, and
A P Fairhead, and
D Muirhead, and
H A Townsend, and
H L Shaw
May 2003,
Drug and alcohol dependence,
S G Brooks, and
R B Christie, and
J Roche, and
A P Fairhead, and
D Muirhead, and
H A Townsend, and
H L Shaw
September 2009,
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,
