In this freeze-fracture study of synaptic terminals of chick photoreceptors, three regions of synaptic terminal plasmalemma can be distinguished on the basis of intramembrane characteristics. The first region is the synaptic vesicle fusion region in which rows of P-face depressions and E-face mounds are observed. In the absence of exocytotic figures this zone is relatively free of P-face particles and E-face pits. Adjacent to this, a second region is seen, rich in P-face particles and complementary E-face pits. This second region waxes and wanes in size during dark and light stimulation (Cooper and McLaughlin, 1982) and may correspond to similar expansions and contractions of synaptic plasmalemma induced by less physiological modes of stimulation, as observed in other synaptic terminals (Ceccarelli et al., 1979b; Model et al., 1975; Boyne and McLeod, 1979). During the waxing period, P-face particles and E-face pits are present in this membrane, and its expansion gives rise to diverticula of the synaptic terminal. During the waning period when the diverticula begin to disappear, aggregates of P-face particles and complementary patches of E-face pits are seen in the diverticular membrane. The third region, the nonsynaptic plasmalemma enclosing the terminal, contains a high density of P-face particles but does not contain E-face pits. Serial sections of vacuoles within the cytoplasm demonstrate that some vacuoles retain connections with this nonsynaptic plasmalemma. Vacuoles that are connected in this way are depleted of intramembrane particles. Such regions appear to represent separate domains within the photoreceptor terminal and are discussed in the context of membrane addition and retrieval.