Enzymes involved in oxygen detoxification during development of Drosophila melanogaster. 1983

H Nickla, and J Anderson, and T Palzkill

Activities of superoxide dismutase (SOD), catalase (CAT), and peroxidases (PER) were examined at 24-h intervals during Drosophila development. SOD activities show a U-shaped curve from egg to adult stages whereas CAT and PER are consistently low in egg through larval stages. Male and female larvae have similar activities of SOD, CAT, and PER whereas male adults have elevated activities of these enzymes. Larvae are more sensitive to H2O2 and 3-amino-1,2,4-triazole (an inhibitor of CAT) than adults.

UI MeSH Term Description Entries
D007814 Larva Wormlike or grublike stage, following the egg in the life cycle of insects, worms, and other metamorphosing animals. Maggots,Tadpoles,Larvae,Maggot,Tadpole
D008297 Male Males
D010544 Peroxidases Ovoperoxidase
D011679 Pupa An inactive stage between the larval and adult stages in the life cycle of INSECTA. Chrysalis,Pupae
D002374 Catalase An oxidoreductase that catalyzes the conversion of HYDROGEN PEROXIDE to water and oxygen. It is present in many animal cells. A deficiency of this enzyme results in ACATALASIA. Catalase A,Catalase T,Manganese Catalase,Mn Catalase
D004331 Drosophila melanogaster A species of fruit fly frequently used in genetics because of the large size of its chromosomes. D. melanogaster,Drosophila melanogasters,melanogaster, Drosophila
D005260 Female Females
D006861 Hydrogen Peroxide A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials. Hydrogen Peroxide (H2O2),Hydroperoxide,Oxydol,Perhydrol,Superoxol,Peroxide, Hydrogen
D000375 Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time. Senescence,Aging, Biological,Biological Aging
D000640 Amitrole A non-selective post-emergence, translocated herbicide. According to the Seventh Annual Report on Carcinogens (PB95-109781, 1994) this substance may reasonably be anticipated to be a carcinogen. (From Merck Index, 12th ed) It is an irreversible inhibitor of CATALASE, and thus impairs activity of peroxisomes. Aminotriazole,3-Amino-1,2,4-triazole

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