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The cis-acting gene regulating specifically the inducibility of lambda 1-bearing B cells has been mapped within 2.9 cM of the structural gene. If the lambda 1lo-phenotype is due to the gly leads to val interchange in C lambda 1, then an argument can be made that (a) the lambda 1lo-phenotype is due to inefficient induction of lambda 1lo-bearing B cells and (b) B cell triggering is dependent upon a conformational change in the Ig receptor upon interaction with antigen. If the lambda 1lo-phenotype is due to a regulatory sequence linked to the structural C lambda 1-gene, then it must control the expression of the lambda 1-locus during development into adulthood, e.g., by an effect on methylation.
R Epstein, and
K Lehmann, and
M Cohn
June 1979,
Diabetes,
R Epstein, and
K Lehmann, and
M Cohn
December 1987,
Proceedings of the National Academy of Sciences of the United States of America,
R Epstein, and
K Lehmann, and
M Cohn
January 1988,
The EMBO journal,
R Epstein, and
K Lehmann, and
M Cohn
January 1987,
Gene,
R Epstein, and
K Lehmann, and
M Cohn
January 1979,
Scandinavian journal of immunology,
R Epstein, and
K Lehmann, and
M Cohn
January 1994,
Immunogenetics,
R Epstein, and
K Lehmann, and
M Cohn
July 1989,
Nucleic acids research,
R Epstein, and
K Lehmann, and
M Cohn
June 1991,
European journal of immunology,
R Epstein, and
K Lehmann, and
M Cohn
January 1981,
Molecular & general genetics : MGG,
R Epstein, and
K Lehmann, and
M Cohn
September 1980,
European journal of immunology,
