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The effect of the prostaglandin synthetase inhibitor indomethacin on the dietary fat enhancement of 7,12-dimethylbenz(a)anthracene-induced mammary tumorigenesis has been examined in female Sprague-Dawley rats. Rats were fed either a normal-fat or high-fat diet (5 or 18% corn oil, respectively) with or without 0.004% indomethacin, starting 3 days after a single intragastric intubation of 5 mg 7,12-dimethylbenz(a)anthracene. Results of this experiment demonstrated that indomethacin completely blocked the stimulatory effect of fat on tumorigenesis, as measured by a decreased tumor incidence, a decreased number of tumors per group, a decreased tumor size, and an increased latency. No effect of indomethacin was observed in rats fed the normal-fat diet. These data suggest that at least part of the stimulatory effect of polyunsaturated fat on 7,12-dimethylbenz(a)anthracene-induced mammary tumorigenesis may be mediated through an increased synthesis of prostaglandins.
C A Carter, and
R J Milholland, and
W Shea, and
M M Ip
May 1991,
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R J Milholland, and
W Shea, and
M M Ip
August 1989,
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R J Milholland, and
W Shea, and
M M Ip
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R J Milholland, and
W Shea, and
M M Ip
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R J Milholland, and
W Shea, and
M M Ip
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R J Milholland, and
W Shea, and
M M Ip
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R J Milholland, and
W Shea, and
M M Ip
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R J Milholland, and
W Shea, and
M M Ip
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R J Milholland, and
W Shea, and
M M Ip
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Cancer research,
