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The hypophysiotropic activities of a synthetic human pancreatic growth hormone releasing factor (hpGRF) with 40 residues was examined in vitro using rat pituitary halves. At concentrations from 10(-10) M to 10(-7) M the peptide stimulated GH release in a dose-dependent manner with the ED50 being 1.2 x 10(-9) M. The concentration of 10(-10) M hpGRF is comparable to the basal hypophyseal portal blood levels of other known hypothalamic hypophysiotropic hormones. However, GH release was enhanced three-fold by concentration as low as 10(-12) M, though no dose-response relationship was observed up to 10(-10) M. Thus, this peptide not only stimulates the release of GH in a dose-dependent manner, but at lower concentrations also maintains elevated GH levels. The release of ACTH, beta-endorphin, LH, and FSH was not affected by hpGRF at any of the concentrations tested. At hpGRF concentrations less than 10(-7) M, the release of TSH and PRL were unaffected. However, at 10(-6) M, TSH release was enhanced about 2.5 fold and prolactin release was elevated slightly.
A Arimura, and
M D Culler, and
C M Turkelson, and
M G Luciano, and
C R Thomas, and
N Obara, and
K Groot, and
J Rivier, and
W Vale
November 1982,
Biochemical and biophysical research communications,
A Arimura, and
M D Culler, and
C M Turkelson, and
M G Luciano, and
C R Thomas, and
N Obara, and
K Groot, and
J Rivier, and
W Vale
January 1986,
Sheng li ke xue jin zhan [Progress in physiology],
A Arimura, and
M D Culler, and
C M Turkelson, and
M G Luciano, and
C R Thomas, and
N Obara, and
K Groot, and
J Rivier, and
W Vale
December 1982,
Proceedings of the National Academy of Sciences of the United States of America,
A Arimura, and
M D Culler, and
C M Turkelson, and
M G Luciano, and
C R Thomas, and
N Obara, and
K Groot, and
J Rivier, and
W Vale
May 1983,
Lancet (London, England),
A Arimura, and
M D Culler, and
C M Turkelson, and
M G Luciano, and
C R Thomas, and
N Obara, and
K Groot, and
J Rivier, and
W Vale
October 1984,
The Journal of clinical endocrinology and metabolism,
A Arimura, and
M D Culler, and
C M Turkelson, and
M G Luciano, and
C R Thomas, and
N Obara, and
K Groot, and
J Rivier, and
W Vale
October 1983,
Endocrinology,
A Arimura, and
M D Culler, and
C M Turkelson, and
M G Luciano, and
C R Thomas, and
N Obara, and
K Groot, and
J Rivier, and
W Vale
March 1985,
Endocrinology,
A Arimura, and
M D Culler, and
C M Turkelson, and
M G Luciano, and
C R Thomas, and
N Obara, and
K Groot, and
J Rivier, and
W Vale
November 1982,
Science (New York, N.Y.),
A Arimura, and
M D Culler, and
C M Turkelson, and
M G Luciano, and
C R Thomas, and
N Obara, and
K Groot, and
J Rivier, and
W Vale
February 1984,
Endocrinologia japonica,
A Arimura, and
M D Culler, and
C M Turkelson, and
M G Luciano, and
C R Thomas, and
N Obara, and
K Groot, and
J Rivier, and
W Vale
May 1984,
The Journal of clinical endocrinology and metabolism,
