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Many gastrointestinal hormones have a stimulating action on the proliferation and growth of stomach and intestinal mucosa and on pancreas. This so-called trophic action was investigated most intensive on gastrin. We reproduced this effect autoradiographically by 3H-thymidine incorporation on the stomach corpus mucosa of rats. The animals had increased serum gastrin levels by partial stomach corpus resection that increased the endogenous serum gastrin level. The proliferation stimulating action of gastrin is also detectable at chronic oral application of N-Methyl-N'-nitroso-N-nitroguanidine for induction of stomach and intestinal tumors simultaneously to pentagastrin administration or partial stomach resection in the intact, tumor free oxyntic mucosa of stomach.
L Jonas, and
M Barten
April 1972,
Gastroenterology,
L Jonas, and
M Barten
November 1973,
The British journal of surgery,
L Jonas, and
M Barten
June 1977,
The Bulletin of Tokyo Medical and Dental University,
L Jonas, and
M Barten
July 1976,
Gut,
L Jonas, and
M Barten
January 1971,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
L Jonas, and
M Barten
April 1973,
Australian and New Zealand journal of medicine,
L Jonas, and
M Barten
December 2003,
The Journal of laboratory and clinical medicine,
L Jonas, and
M Barten
November 2006,
American journal of physiology. Gastrointestinal and liver physiology,
L Jonas, and
M Barten
February 1974,
Gut,
L Jonas, and
M Barten
May 1973,
Archives of surgery (Chicago, Ill. : 1960),
