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Cold pressor test and variant angina. 1983

T Kawano, and M Okabe, and K Arakawa

A transient complete coronary occlusion due to spasm was induced by the cold pressor test in a 51-year-old man with variant angina. Arteriography before the test revealed a normal left coronary artery and only minor irregularities of the mid-portion of the right coronary artery. Three minutes after cold stimulation, angina pectoris accompanied by ST-segment elevation was observed in lead II ECG. Simultaneous coronary arteriography during the attack showed a complete occlusion of the proximal right coronary artery due to spasm. The anginal attack together with spastic occlusion disappeared after administration of 0.8 mg of nitroglycerin. Thus, the cold pressor test can trigger coronary artery spasm and may even lead to a total occlusion in patients with variant angina. Individuals with variant angina may be subjected to additional risk when exposed to cold temperatures.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D003080 Cold Temperature An absence of warmth or heat or a temperature notably below an accustomed norm. Cold,Cold Temperatures,Temperature, Cold,Temperatures, Cold
D003329 Coronary Vasospasm Spasm of the large- or medium-sized coronary arteries. Coronary Artery Spasm,Coronary Artery Vasospasm,Artery Spasm, Coronary,Artery Vasospasm, Coronary,Coronary Artery Spasms,Coronary Artery Vasospasms,Coronary Vasospasms,Spasm, Coronary Artery,Vasospasm, Coronary,Vasospasm, Coronary Artery
D004562 Electrocardiography Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY. 12-Lead ECG,12-Lead EKG,12-Lead Electrocardiography,Cardiography,ECG,EKG,Electrocardiogram,Electrocardiograph,12 Lead ECG,12 Lead EKG,12 Lead Electrocardiography,12-Lead ECGs,12-Lead EKGs,12-Lead Electrocardiographies,Cardiographies,ECG, 12-Lead,EKG, 12-Lead,Electrocardiograms,Electrocardiographies, 12-Lead,Electrocardiographs,Electrocardiography, 12-Lead
D005996 Nitroglycerin A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives. Glyceryl Trinitrate,Anginine,Dynamite,Gilustenon,Nitrangin,Nitro-Bid,Nitro-Dur,Nitrocard,Nitroderm,Nitroderm TTS,Nitroglyn,Nitrol,Nitrolan,Nitrong,Nitrospan,Nitrostat,Perlinganit,Susadrin,Sustac,Sustak,Sustonit,Transderm Nitro,Tridil,Trinitrin,Trinitrolong,Nitro Bid,Nitro Dur,NitroBid,NitroDur,Trinitrate, Glyceryl
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000788 Angina Pectoris, Variant A clinical syndrome characterized by the development of CHEST PAIN at rest with concomitant transient ST segment elevation in the ELECTROCARDIOGRAM, but with preserved exercise capacity. Prinzmetal Angina,Prinzmetal's Angina,Angina, Prinzmetal,Angina, Prinzmetal's,Prinzmetals Angina,Variant Angina Pectoris

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