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Radioimmunoassays for IgM and IgG histoplasmal antibodies were developed and proved to be specific for their respective immunoglobulin classes, sensitive, and reproducible. Elevated IgM antibodies were detected in 59.8% of patients with histoplasmosis and 7.9% of control subjects. Elevated IgG antibodies occurred in 80.4% of patients with histoplasmosis but in only 12.9% of control subjects. Radioimmunoassay was nearly twice as sensitive as complement fixation for identifying patients with mild, presumably asymptomatic, infection. Of 13 patients with serologic follow-up at least 1 yr later, elevated IgM antibodies cleared, whereas IgG antibodies persisted in 7. In an epidemiologic investigation of a recurrent histoplasmosis outbreak, only the radioimmunoassay was able to prove the hypothesis that construction for a swimming complex was the source of exposure. These assays promise to be useful for clinical and epidemiologic investigations.
L J Wheat, and
R B Kohler, and
M L French, and
M Garten, and
M Kleiman, and
S E Zimmerman, and
W Schlech, and
J Ho, and
A White, and
Z Brahmi
April 1988,
Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology,
L J Wheat, and
R B Kohler, and
M L French, and
M Garten, and
M Kleiman, and
S E Zimmerman, and
W Schlech, and
J Ho, and
A White, and
Z Brahmi
November 1973,
Infection and immunity,
L J Wheat, and
R B Kohler, and
M L French, and
M Garten, and
M Kleiman, and
S E Zimmerman, and
W Schlech, and
J Ho, and
A White, and
Z Brahmi
January 2017,
Frontiers in bioengineering and biotechnology,
L J Wheat, and
R B Kohler, and
M L French, and
M Garten, and
M Kleiman, and
S E Zimmerman, and
W Schlech, and
J Ho, and
A White, and
Z Brahmi
January 1989,
Journal of clinical microbiology,
L J Wheat, and
R B Kohler, and
M L French, and
M Garten, and
M Kleiman, and
S E Zimmerman, and
W Schlech, and
J Ho, and
A White, and
Z Brahmi
June 1976,
European journal of immunology,
L J Wheat, and
R B Kohler, and
M L French, and
M Garten, and
M Kleiman, and
S E Zimmerman, and
W Schlech, and
J Ho, and
A White, and
Z Brahmi
October 1985,
The American review of respiratory disease,
L J Wheat, and
R B Kohler, and
M L French, and
M Garten, and
M Kleiman, and
S E Zimmerman, and
W Schlech, and
J Ho, and
A White, and
Z Brahmi
April 1987,
Nihon juigaku zasshi. The Japanese journal of veterinary science,
L J Wheat, and
R B Kohler, and
M L French, and
M Garten, and
M Kleiman, and
S E Zimmerman, and
W Schlech, and
J Ho, and
A White, and
Z Brahmi
October 1982,
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi,
L J Wheat, and
R B Kohler, and
M L French, and
M Garten, and
M Kleiman, and
S E Zimmerman, and
W Schlech, and
J Ho, and
A White, and
Z Brahmi
January 1970,
Bulletin of the World Health Organization,
L J Wheat, and
R B Kohler, and
M L French, and
M Garten, and
M Kleiman, and
S E Zimmerman, and
W Schlech, and
J Ho, and
A White, and
Z Brahmi
February 1979,
Journal of clinical microbiology,
