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The genotoxic activity of four mycotoxins has been studied. High level of somatic mutagenesis in imaginal discs of Drosophila melanogaster larvae and DNA repair synthesis in human embryo and adult rat liver cell cultures were inducible only by highly carcinogenic aflatoxin B1. Patulin, a weak direct-action carcinogenic substance, slightly elevated the mutagenesis in somatic cells of Drosophila but did not induce DNA repair synthesis in liver cell cultures. Citrinin that did not exhibit any carcinogenic properties when used alone and stachybotrotoxin with non-reported carcinogenic activity appeared inactive in the test-systems applied. The possibilities of rapid recognition of carcinogenic mycotoxins by detecting their genotoxic properties are discussed.
G A Belitskiĭ, and
E M Khovanova, and
I V Budunova, and
E G Sharunich
June 1985,
Cell biology and toxicology,
G A Belitskiĭ, and
E M Khovanova, and
I V Budunova, and
E G Sharunich
January 1989,
Environmental and molecular mutagenesis,
G A Belitskiĭ, and
E M Khovanova, and
I V Budunova, and
E G Sharunich
January 1977,
Methods in cell biology,
G A Belitskiĭ, and
E M Khovanova, and
I V Budunova, and
E G Sharunich
March 1967,
Genetics,
G A Belitskiĭ, and
E M Khovanova, and
I V Budunova, and
E G Sharunich
May 2005,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
G A Belitskiĭ, and
E M Khovanova, and
I V Budunova, and
E G Sharunich
January 2004,
Doklady. Biochemistry and biophysics,
G A Belitskiĭ, and
E M Khovanova, and
I V Budunova, and
E G Sharunich
January 1984,
The British journal of cancer. Supplement,
G A Belitskiĭ, and
E M Khovanova, and
I V Budunova, and
E G Sharunich
April 2020,
DNA repair,
G A Belitskiĭ, and
E M Khovanova, and
I V Budunova, and
E G Sharunich
February 1985,
Carcinogenesis,
G A Belitskiĭ, and
E M Khovanova, and
I V Budunova, and
E G Sharunich
June 1987,
Radiation research,
