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This study evaluated respiratory and cardiovascular responses of canines in whom bilateral bronchopleural fistulae were created surgically, and in whom ventilation was varied between intermittent positive pressure ventilation (IPPV) and high frequency ventilation (HFV). An Emerson prototype ventilator was used for HFV at rates of 300-1400/min at driving pressures of 2.5, 5.0, and 10 psi. Gas exchange was judged by arterial and mixed venous blood gases. Cardiac performance was measured by cardiac index, heart rate, stroke index, stroke work index, systemic and pulmonary vascular pressures and resistances. Ventilation during IPPV with the fistula open resulted in a statistically significant increase in PaCO2 and a decrease in PaO2 when compared to both HFV modes. Variations in cardiac function in these open-chested animals were insignificant for all variables tested except pulmonary artery pressures which rose significantly in the IPPV group.
B H Hoff, and
E Wilson, and
R B Smith, and
E Bennett, and
W Philips
February 1982,
Critical care medicine,
B H Hoff, and
E Wilson, and
R B Smith, and
E Bennett, and
W Philips
January 1987,
Acta anaesthesiologica Belgica,
B H Hoff, and
E Wilson, and
R B Smith, and
E Bennett, and
W Philips
October 1987,
Acta anaesthesiologica Scandinavica,
B H Hoff, and
E Wilson, and
R B Smith, and
E Bennett, and
W Philips
January 1986,
Revista paulista de medicina,
B H Hoff, and
E Wilson, and
R B Smith, and
E Bennett, and
W Philips
January 1984,
Scandinavian journal of thoracic and cardiovascular surgery,
B H Hoff, and
E Wilson, and
R B Smith, and
E Bennett, and
W Philips
September 1984,
Critical care medicine,
B H Hoff, and
E Wilson, and
R B Smith, and
E Bennett, and
W Philips
February 1980,
Anesthesiology,
B H Hoff, and
E Wilson, and
R B Smith, and
E Bennett, and
W Philips
March 1981,
Resuscitation,
B H Hoff, and
E Wilson, and
R B Smith, and
E Bennett, and
W Philips
February 1984,
Journal of the National Medical Association,
B H Hoff, and
E Wilson, and
R B Smith, and
E Bennett, and
W Philips
January 1985,
Pediatric pulmonology,
