Biomaterial Database

Effects of retrograde luminal perfusion of the canine jejunum on intestinal absorption and myoelectrical activity. 1983

A Mitchell, and J Collin, and T G Denton

The effects of retrograde luminal perfusion of a 75 cm jejunal segment on absorption, transit time and myoelectrical activity were studied in four dogs. Retrograde perfusion increased jejunal absorption of water (0.016-0.021 ml cm intestinal length-1 min-1. P less than 0.001) together with sodium (1.15-1.82 mumol cm-1 min-1; P less than 0.001) and glucose (1.98-2.27 mumol cm-1 min-1; P less than 0.01). Mean jejunal transit time was prolonged (9.2-13.9 min; P less than 0.001) and jejunal spike activity was reduced compared with antegrade perfusion (14.5-4% of slow wave frequency; P less than 0.01). These results suggest that the reversal of small bowel segments in the treatment of the short bowel syndrome can result in an increase in absorption from the reversed segment itself in addition to any effect from delayed transit in the proximal bowel.

UI	MeSH Term	Description	Entries
D007408	Intestinal Absorption	Uptake of substances through the lining of the INTESTINES.	Absorption, Intestinal
D007583	Jejunum	The middle portion of the SMALL INTESTINE, between DUODENUM and ILEUM. It represents about 2/5 of the remaining portion of the small intestine below duodenum.	Jejunums
D010477	Perfusion	Treatment process involving the injection of fluid into an organ or tissue.	Perfusions
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D004594	Electrophysiology	The study of the generation and behavior of electrical charges in living organisms particularly the nervous system and the effects of electricity on living organisms.
D005260	Female		Females
D005947	Glucose	A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.	Dextrose,Anhydrous Dextrose,D-Glucose,Glucose Monohydrate,Glucose, (DL)-Isomer,Glucose, (alpha-D)-Isomer,Glucose, (beta-D)-Isomer,D Glucose,Dextrose, Anhydrous,Monohydrate, Glucose
D000200	Action Potentials	Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.	Spike Potentials,Nerve Impulses,Action Potential,Impulse, Nerve,Impulses, Nerve,Nerve Impulse,Potential, Action,Potential, Spike,Potentials, Action,Potentials, Spike,Spike Potential
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012778	Short Bowel Syndrome	A malabsorption syndrome resulting from extensive operative resection of the SMALL INTESTINE, the absorptive region of the GASTROINTESTINAL TRACT.	Bowel Syndrome, Short,Bowel Syndromes, Short,Short Bowel Syndromes,Syndrome, Short Bowel,Syndromes, Short Bowel